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MetabolomicsGrowth control of the eukaryote cell: a systems biology study in yeast
Metabolic control analysis is being exploited in a systems biology study of the eukaryotic cell. Using chemostat culture, we have measured the impact of changes in flux (growth rate) on the transcriptome, proteome, endometabolome and exometabolome of the yeast Saccharomyces cerevisiae. Each function...
2012-04-19 | MTBLS8 | MetaboLights
MetabolomicsA conserved metabolic signature associated with response to fast-acting antimalarial agents

Characterizing the mode of action of antimalarial compounds that emerge from high-throughput phenotypic screens is central to understanding how parasite resistance to these drugs can emerge. Here, we have employed untargeted metabolomics to inform on the mechanism of action of antimalarial leads ...

2023-09-27 | MTBLS6580 | MetaboLights
TranscriptomicsExpression profiling of exposure to phorbol myristate acetate - PMA and FOXK2 depletion with siRNA
Expression profiling was done of exposure to phorbol myristate acetate -PMA and FOXK2 depletion by siRNA transfection. This was done on the human osteosarcoma U2OS cell line which stably expresses FOXK2. PMA is an inducer of AP1 activity.
ORGANISM(S): Homo sapiens 
2011-11-03 | E-MEXP-3107 | biostudies-arrayexpress
TranscriptomicsExpression profiling of FOXK2 depletion by siRNA
Expression profiling was done of FOXK2 depletion by siRNA transfection. This was done on the human osteosarcoma U2OS cell line (which stably expresses FOXK2).
ORGANISM(S): Homo sapiens 
2011-11-03 | E-MEXP-3106 | biostudies-arrayexpress
TranscriptomicsEndo-siRNAs in C. elegans spermatogenesis and their requirement for the RdRP RRF-3
Short interfering RNAs (siRNAs) are a class of regulatory effectors that enforce gene silencing though formation of RNA duplexes. While progress has been made in identifying the capabilities of siRNAs in silencing of foreign RNA and transposable elements, siRNA functions in endogenous gene regulatio...
ORGANISM(S): Caenorhabditis elegans 
2010-01-13 | E-GEOD-18429 | biostudies-arrayexpress
GenomicsA Basophil-Fibroblast Pro-inflammatory Axis Fuels Type 2 Skin Inflammation
A Basophil-Fibroblast Pro-inflammatory Axis Fuels Type 2 Skin Inflammation
PRJNA1216627 | ENA
MetabolomicsMicrobial liberation of N-methylserotonin from orange fiber in gnotobiotic mice and humans
Plant fibers in byproduct streams produced by non-harsh food processing methods represent biorepositories of diverse, naturally occurring, and physiologically active biomolecules. To demonstrate one approach for their characterization, mass spectrometry of intestinal contents from gnotobiotic mice, ...
2022-07-28 | MTBLS2331 | MetaboLights
GenomicsA Basophil-Fibroblast Pro-inflammatory Axis Fuels Type 2 Skin Inflammation [scRNA-Seq]
A Basophil-Fibroblast Pro-inflammatory Axis Fuels Type 2 Skin Inflammation [scRNA-Seq]
PRJNA1216633 | ENA
GenomicsA Basophil-Fibroblast Pro-inflammatory Axis Fuels Type 2 Skin Inflammation [RNA-Seq]
A Basophil-Fibroblast Pro-inflammatory Axis Fuels Type 2 Skin Inflammation [RNA-Seq]
PRJNA1216304 | ENA
GenomicsETV1 ChIP-seq in OE33 esophageal adenocarcinoma cells
Chromatin immunoprecipitation using anti-ETV1 a.k.a. ER81 (Abcam: ab81086) antibodies or input DNA in an OE33 cell line
ORGANISM(S): Homo sapiens 
2017-07-07 | E-MTAB-5168 | biostudies-arrayexpress
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