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TranscriptomicsExpression data from E11.5 mouse embryonic forelimbs - various mutant conditions or dissected limb domains
Sonic hedgehog (Shh) signals via Gli transcription factors to direct digit number and identity in the vertebrate limb. We have characterized the Gli-dependent cis-regulatory network through a combination of whole genome ChIP-on-chip and transcriptional profiling of the developing mouse limb. In this...
ORGANISM(S): Mus musculus 
2008-09-14 | E-GEOD-11063 | biostudies-arrayexpress
GenomicsA high-resolution view of transcription and chromatin states across distinct metabolic states in budding yeast
Under continuous, glucose-limited conditions, budding yeast exhibit robust metabolic cycles associated with major oscillations of gene expression and metabolic state. However, how such fluctuations might be coordinately linked to changes in chromatin status is less well understood. Here, we examine ...
ORGANISM(S): Saccharomyces cerevisiae 
2014-08-31 | E-GEOD-52339 | biostudies-arrayexpress
TranscriptomicsGene expression comparison between undifferentiated H9 cells and trophoblasts
Undifferentiated H9 express high levels of c-Myc. Upon differentiation, Myc levels decrease. Gene expression analysis was carried out between these 2 cell types H9 cells were treated with BMP-4 for 6 days in order to differentiate them toward a trophoblast lineage.
ORGANISM(S): Homo sapiens 
2011-09-18 | E-GEOD-31965 | biostudies-arrayexpress
TranscriptomicsGene expression from human B-lymphocytes (P493-6)
P493-6 contain a tet repressible MYC contruct. In the presense of tetracycline, MYC levels are great reduced and the cells cease to cycle. Gene expression was compared between high and low MYC expressing cells P493-6 cells were grown in both the presence and absence of tetracycline. RNA was extra...
ORGANISM(S): Homo sapiens 
2011-09-18 | E-GEOD-32219 | biostudies-arrayexpress
TranscriptomicsGata6 potently initiates reprogramming of pluripotent and differentiated cells to extraembryonic endoderm stem cells [ChIP-Seq & RNA-Seq]
Transcription factor-mediated reprogramming is a powerful method to study cell fate changes. In this work, we demonstrate that the transcription factor Gata6 can initiate reprograming of multiple cell types to induced extraembryonic endoderm (iXEN) cells. Intriguingly, Gata6 is sufficient to drive i...
ORGANISM(S): Homo sapiens 
2015-06-30 | E-GEOD-69322 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of embryoid bodies treated with retinoic-acid or retinoic-acid + hedgehog agonist to measure neural targets of sonic hedgehog signaling
This experiment was specifically designed to measure neural targets of Shh signaling, we sought to profile the genes upregulated by Hh signaling in the ventral neural tube to obtain a valid dataset. To obtain ventral-specific markers, we generated retinoic acid-treated EBs grown in the presence or ...
ORGANISM(S): Mus musculus 
2007-11-22 | E-GEOD-4936 | biostudies-arrayexpress
TranscriptomicsMLL Fusion Proteins Preferentially Regulate a Small Set of Wild Type MLL Target Genes in the Leukemic Genome
MLL encodes a histone methyltransferase that is critical in maintaining gene expression during embryonic development and hematopoiesis. 11q23 translocations encode chimeric MLL fusions that act as potent drivers of acute leukemia. However, it remains unclear what portion of the leukemic genome is un...
ORGANISM(S): Mus musculus 
2011-04-28 | E-GEOD-24794 | biostudies-arrayexpress
TranscriptomicsFoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis.
Activated phosphoinositide 3-kinase (PI3K)-AKT signaling appears to be an obligate event in the development of cancer. The highly related members of the mammalian FoxO transcription factor family, FoxO1, FoxO3, and FoxO4, represent one of several effector arms of PI3K-AKT signaling, prompting geneti...
ORGANISM(S): Mus musculus 
2011-03-16 | E-GEOD-27932 | biostudies-arrayexpress
UnknownMolecular deconvolution of the neutralizing antibodies induced by an inactivated SARS-CoV-2 virus vaccine.
Not available
S-EPMC8080482 | biostudies-literature
TranscriptomicsGata6 potently initiates reprogramming of pluripotent and differentiated cells to extraembryonic endoderm stem cells [time-course microarray]
Transcription factor-mediated reprogramming is a powerful method to study cell fate changes. In this work, we demonstrate that the transcription factor Gata6 can initiate reprograming of multiple cell types to induced extraembryonic endoderm (iXEN) cells. Intriguingly, Gata6 is sufficient to drive i...
ORGANISM(S): Mus musculus 
2015-06-30 | E-GEOD-69321 | biostudies-arrayexpress
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