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ProteomicsIdentifying interaction partners of noncanonical peptides.
Studies have revealed dozens of functional peptides in putative ‘noncoding’ regions and raised the question of how many proteins are encoded by noncanonical open reading frames (ORFs). We comprehensively annotated genome-wide translated ORFs across five eukaryotic by analyzing ribosome profiling rea...
ORGANISM(S): Homo sapiens (Human) 
2024-05-23 | PXD037658 | Pride
Human Interaction protein Mass spectrometry Noncanonical open reading frames (ncorfs) Peptide 
TranscriptomicsProgressive lengthening of 3' untranslated regions of mRNAs by alternative polyadenylation during mouse embryonic development
The 3' untranslated regions (3' UTRs) of mRNAs contain cis-acting elements for posttranscriptional regulation of gene expression. Here, we report that mouse genes tend to express mRNAs with longer 3' UTRs as embryonic development progresses. This global regulation is controlled by alternative polyad...
ORGANISM(S): Mus musculus 
2010-08-31 | E-GEOD-23871 | biostudies-arrayexpress
TranscriptomicsTranscriptional activity regulates alternative cleavage and polyadenylation
Genes containing multiple polyadenylation (polyA) sites express mRNA isoforms with variable 3’ untranslated regions (3’UTRs). We found that short and long 3’UTR isoforms were relatively more abundant when genes were highly and lowly expressed, respectively, in human and mouse cells. Consistently, up...
ORGANISM(S): Mus musculus 
2011-08-15 | E-GEOD-26512 | biostudies-arrayexpress
TranscriptomicsAnalysis of Caenorhabditis elegans intestinal gene expression and alternative polyadenylation using fluorescence-activated nuclei sorting (FANS) and 3' end deep sequencing (3'end-seq)
Caenorhabditis elegans is a major eukaryotic experimental system employed to unravel a broad range of cellular and biological processes. Despite the many advantages of C. elegans, biochemical approaches to study tissue-specific gene expression in postembryonic stages are challenging. Here we report ...
ORGANISM(S): Caenorhabditis elegans 
2011-12-01 | E-GEOD-32165 | biostudies-arrayexpress
ProteomicsMorphological change of gill and activation of cell phagocytosis pathway through differential proteomics in Mytilus coruscus under starvation
Mytilus coruscus are one of the dominant shellfish in the Yangtze estuary, but they often face food deprivation due to seasonal fluctuations in algal abundance caused by seasonal freshwater flushing and high-density aquaculture. To investigate the coping strategies of M. coruscus to starvation stres...
ORGANISM(S): Mytilus Coruscus 
2023-03-16 | PXD040908 |
ProteomicsPlatelet proteomics reveals mechanism of platelet activation inhibition by AEE
A platelet proteomic approach to reveal the regulatory network by which AEE inhibits platelet activation, thereby preventing thrombosis.
ORGANISM(S): Rattus Rattus 
2024-08-14 | PXD054906 |
UnknownImmunocompromised patients with acute respiratory distress syndrome: secondary analysis of the LUNG SAFE database.
Not available
S-EPMC5998562 | biostudies-literature
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