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TranscriptomicsTransactivation-deficient p53 Mutants in Ras-induced Cellular Senescence
As a critical cellular stress sensor, p53 mediates a variety of defensive processes including cell-cycle arrest, apoptosis, and senescence to prevent propagation of hyperproliferative cells or cells with a damaged genome, hence the formation of neoplasia. Transactivation of downstream genes plays an...
ORGANISM(S): Mus musculus 
2011-05-13 | E-GEOD-27901 | biostudies-arrayexpress
TranscriptomicsExpression data from salivary tumor tissues derived from MMTV-ras transgenic mice with wild-type p53, no p53 or gain-of-function mutant p53
Salivary tumors isolated from MMTV-ras transgenic mice expressing wild-type p53, no p53 or p53R172H gain-of-funcion mutant were subjected to genome-wide gene expression profiling to assess the effect of the different p53 status on tumor gene expression. A total of 12 spontaneous salivary tumors from...
ORGANISM(S): Mus musculus 
2014-08-15 | E-GEOD-59452 | biostudies-arrayexpress
UnknownGlobal, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016.
Not available
S-EPMC5605707 | biostudies-literature
UnknownGlobal, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016.
Not available
S-EPMC5605509 | biostudies-literature
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