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UnknownKPT330 improves Cas9 precision genome- and base-editing by selectively regulating mRNA nuclear export.
CRISPR-based genome engineering tools are associated with off-target effects that constitutively active Cas9 protein may instigate. Previous studies have revealed the feasibility of modulating Cas9-based genome- and base-editing tools using protein or small-molecule CRISPR inhibitors. Here we screen...
S-EPMC8931069 | biostudies-literature
UnknownSpecific pupylation as IDEntity reporter (SPIDER) for the identification of protein-biomolecule interactions.
Protein-biomolecule interactions play pivotal roles in almost all biological processes. For a biomolecule of interest, the identification of the interacting protein(s) is essential. For this need, although many assays are available, highly robust and reliable methods are always desired. By combining...
S-EPMC10103678 | biostudies-literature
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