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ProteomicsDiscovery of a monoacylglycerol lipase inhibitor that harnesses the therapeutic potential of endocannabinoid signaling without CNS-mediated adverse side effects or physical dependence.
Chemical proteomics of LEI-515 in mouse lung, liver and brain tissue to assess the selectivity of the inhibitor.
ORGANISM(S): Mus musculus (Mouse) 
2023-10-09 | PXD042220 | Pride
Brain Lung Liver Mouse Chemical proteomics 
TranscriptomicsExpression analysis of Streptomyces avermitilis NRRL8165 delta-aveI mutant
Investigation of whole genome gene expression level changes in Streptomyces avermitilis delta-aveI mutant, compared to the wild-type strain. The mutants analyzed in this study are further described in Chen L, Lu Y., Chen J, Zhang W, Shu D, Qin Z, Yang S, Jiang W. (2008) Characterization of a negativ...
ORGANISM(S): Streptomyces avermitilis 
2010-05-16 | E-GEOD-16892 | biostudies-arrayexpress
UnknownGenetic and antigenic analysis of mink's immunoglobulin G Fc region.
Not available
S-EPMC4439980 | biostudies-literature
MetabolomicsMetabolomic analysis of alfalfa (Medicago sativa L.) root-symbiotic rhizobia responses under alkali stress
Alkaline salts (e.g., NaHCO3 and Na2CO3) causes more severe morphological and physiological damage to plants than neutral salts (e.g., NaCl and Na2SO4) due to differences in pH. The mechanism by which plants respond to alkali stress is not fully understood, especially in plants having symbotic relat...
2018-07-27 | MTBLS481 | MetaboLights
UnknownAnanas comosus L. Leaf Phenols and p-Coumaric Acid Regulate Liver Fat Metabolism by Upregulating CPT-1 Expression.
Not available
S-EPMC4145745 | biostudies-literature
TranscriptomicsRegulatory RNA Apela Is a Component of a Negative Feedback Loop Regulating p53-Mediated Apoptosis in Embryonic Stem Cells (III)
The goal is to identify RNAs that bind to Hnrnpl (hnRNP L) using RNA immunoprecipitation (RIP) assay. p53+/+ mES cells and p53-/- mES cells were untreated or treated with 0.5 uM Adriamycin for 8 hours. RNA immunoprecipitation was performed using Hnrnpl antibody (Bethyl, Cat#: A311-423A). Total RNA w...
ORGANISM(S): Mus musculus 
2015-06-05 | E-GEOD-62378 | biostudies-arrayexpress
GenomicsEpigenetic marks and factors binding to chromatin in mouse embryonic stem cells
The goal is to profile several histone modifications and hnRNP L in untreated or Adriamycin-treated mouse embryonic stem cells. Fifty million of R1E mES cells were untreated or treated with 0.5 uM Adriamycin for 8 hours. Fixed cells were subject to ChIP-seq assay.
ORGANISM(S): Mus musculus 
2015-06-05 | E-GEOD-62864 | biostudies-arrayexpress
UnknownA monoacylglycerol lipase inhibitor showing therapeutic efficacy in mice without central side effects or dependence.
Not available
S-EPMC10698032 | biostudies-literature
UnknownSustained delivery of calcium and orthophosphate ions from amorphous calcium phosphate and poly(L-lactic acid)-based electrospinning nanofibrous scaffold.
Not available
S-EPMC5374505 | biostudies-literature
MetabolomicsSalmonella Typhimurium reprograms macrophage metabolism via T3SS effector SopE2 to promote intracellular replication and virulence

Salmonella Typhimurium establishes systemic infection by replicating in host macrophages. Here we show that macrophages infected with S. Typhimurium exhibit upregulated glycolysis and decreased serine synthesis, leading to accumulation of glycolytic intermediates. The effects on...

2024-05-22 | MTBLS2347 | MetaboLights
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