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MetabolomicsSalmonella Typhimurium reprograms macrophage metabolism via T3SS effector SopE2 to promote intracellular replication and virulence

Salmonella Typhimurium establishes systemic infection by replicating in host macrophages. Here we show that macrophages infected with S. Typhimurium exhibit upregulated glycolysis and decreased serine synthesis, leading to accumulation of glycolytic intermediates. The effects on...

2024-05-22 | MTBLS2347 | MetaboLights
UnknownDiosbulbin C, a novel active ingredient in Dioscorea bulbifera L. extract, inhibits lung cancer cell proliferation by inducing G0/G1 phase cell cycle arrest.
Not available
S-EPMC10694954 | biostudies-literature
TranscriptomicsRNA-seq of the primary patient-derived GBM cell line G797 following siRNA-mediated knockdown and pcDNA3.1-Neomycin-mediated overexpression of the lncRNA HOXA10-AS
We used a machine-learning framework to systematically discover prognostic long non-coding RNAs (lncRNAs) in 9,446 patient tumors of 30 types. We identified 166 prognostic lncRNAs whose transcript abundance correlated with patient risk and improved the performance of common clinical variables and mo...
ORGANISM(S): Homo sapiens 
2021-10-02 | E-MTAB-10944 | biostudies-arrayexpress
UnknownBTN3A1 expressed in cervical cancer cells promotes Vγ9Vδ2 T cells exhaustion through upregulating transcription factors NR4A2/3 downstream of TCR signaling.
Not available
S-EPMC11439235 | biostudies-literature
UnknownStructural Insights into an Antiparallel Chair-Type G-Quadruplex From the Intron of NOP56 Oncogene.
Not available
S-EPMC12021085 | biostudies-literature
UnknownDecreased RYR2 Cluster Size and Abnormal SR Ca<sup>2+</sup> Release Contribute to Arrhythmogenesis in TMEM43-Related ARVC.
Not available
S-EPMC12677635 | biostudies-literature
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