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MetabolomicsOsh2 mediates Candida resistance to miltefosine by regulating zymosterol transport
Miltefosine has been identified for its antifungal properties, yet the mechanisms underlying its action and the development of resistance remain unclear. In this study, we induced drug resistance in various Candida species through concentration gradient exposure, successfully obtaining a miltefosine...
2025-07-03 | MTBLS12270 | MetaboLights
TranscriptomicsRNA-Seq of human aortic endothelial cells with lysophosphatidylcholine, IL-35, and IL-10 against controls
Human aortic endothelial cells were stimulated by lysophosphatidylcholine (LPC) (10μM) with or without interleukin 35 (IL-35) (10ng/mL) or IL-10 (10ng/mL) for 18 hours. Total RNAs were extracted from samples, then mRNA and non-coding RNAs were enriched by removing rRNA from the total RNA. The libr...
ORGANISM(S): Homo sapiens 
2019-10-28 | E-MTAB-6604 | biostudies-arrayexpress
ProteomicsEIF5A couples translational control with transcriptional reprogramming through chromocenter reorganization during spermiogenesis
Translation initiation factor eIF5A facilitates protein synthesis and impacts diverse biological processes, yet its role in transcriptional regulation is poorly understood. Here we find eIF5A highly expressed in diverse spermatogenic cell types. Conditional knockout of Eif5a (SKO) causes complete in...
ORGANISM(S): Mus Musculus 
2025-08-12 | PXD067244 |
ProteomicsA Recombinant Vaccine Targeting Receptor-binding Domain of SARS-CoV-2 Spike Protein Induces Protective Immunity in Mice and Non-human Primates
The novel Coronavirus SARS-CoV-2 causes a respiratory illness called COVID-19 leading to a pandemic. An effective preventive vaccine against this virus is urgently needed.
ORGANISM(S): Severe Acute Respiratory Syndrome Coronavirus 2 
2020-07-30 | PXD020653 |
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