CD73 (ecto-5'-nucleotidase) is a metabolic immune checkpoint that dephosphorylates AMP to produce adenosine. Adenosine plays a pivotal role in immunosuppressive tumor microenvironment (TME) through adenosine receptors expressed on various immune cells. AB680, a specific CD73 inhibitor, is currently ...
Biotinylated proteins were enriched with streptavidin beads followed by on-bead trypsin digestion. Then the LC-MS/MS analysis was performed to identify the biotinylated proteins.
