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TranscriptomicsTranscription profiling of human lymphoblastoid cell lines (LCLs) derived from ICF syndrome and normal individuals.
Genome-wide DNA methylation patterns are established and maintained by the coordinated action of three DNA methyltransferases, DNMT1, DNMT3A, and DNMT3B. DNMT3B hypomorphic germline mutations are responsible for two-thirds of Immunodeficiency, Centromere Instability, Facial Anomalies (ICF) syndrome ...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-9499 | biostudies-arrayexpress
TranscriptomicsExpression data from human cancer cells
We used microarrays to profile gene expression of NCCIT cells to study the link between epigenetic modifications and gene transcription. Extract total RNA to examine gene expression of NCCIT cells in the undifferentiated and differentiated states.
ORGANISM(S): Homo sapiens 
2012-10-19 | E-GEOD-38936 | biostudies-arrayexpress
GenomicsProfiling of Chromatin States in a Human Cancer Cell Line
DNA methylation mediated by the combined action of three DNA methyltransferases, DNMT1, DNMT3A, and DNMT3B, is essential for mammalian development and is also a major contributor to transformation. To elucidate how DNA methylation is targeted, we map the genome-wide localization of all DNMTs and met...
ORGANISM(S): Homo sapiens 
2012-10-19 | E-GEOD-38937 | biostudies-arrayexpress
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