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GenomicsGcn5 and PCAF negatively regulate interferon β production through HAT-independent inhibition of TBK1 [ChIP-Seq]
Gcn5/PCAF dobule knockout (dKO) in MEFs leads to loss of the global H3K9ac, but only affect expression of a small nubmer of genes according to RNA-Seq data. To examine the function of H3K9ac on gene activation, H3K9ac ChIP-Seq was performed. We found that H3K9ac at Transcriptional Start sites (TSSs)...
ORGANISM(S): Mus musculus 
2014-09-03 | E-GEOD-60967 | biostudies-arrayexpress
TranscriptomicsGcn5 and PCAF negatively regulate interferon β production through HAT-independent inhibition of TBK1 [RNA-Seq]
Gcn5/PCAF double knockout (dKO) leads to loss of the global H3K9ac. RNA-Seq was performed to define the changes of gene expression in response to Gcn5/PCAF deletion and H3K9ac loss PCAF-/-;Gcn5f/D MEFs were infected with retroviral Cre to delete Gcn5 to generate Gcn5/PCAF dKO cells, followed by RNA-...
ORGANISM(S): Mus musculus 
2014-09-03 | E-GEOD-60968 | biostudies-arrayexpress
TranscriptomicsT lymphocytes from Chronic HCV-infected patients express unique pro-apoptotic gene signature.
Although extensive studies have demonstrated the gene expression patterns of antigen-specific CD4+ and CD8+ T-cells during chronic hepatitis C virus (HCV) infection, the transcriptional profiles of global CD4+ and CD8+ T-cells remains unclear. In this report, we recruited 10 long-term (~20 years) tr...
ORGANISM(S): Homo sapiens 
2013-08-19 | E-GEOD-49954 | biostudies-arrayexpress
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