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UnknownActivation, Impaired Tumor Necrosis Factor-α Production, and Deficiency of Circulating Mucosal-Associated Invariant T Cells in Patients with Scrub Typhus.

Background

Mucosal-associated invariant T (MAIT) cells contribute to protection against certain microorganism infections. However, little is known about the role of MAIT cells in Orientia tsutsugamushi infection. Hence, the aims of this study were to examine the level and function of MAIT ce...
S-EPMC4963088 | biostudies-literature
UnknownToward redesigning the PEG surface of nanocarriers for tumor targeting: impact of inner functionalities on size, charge, multivalent binding, and biodistribution.
Achieving accurate and efficacious tumor targeting with minimal off-target effects is of paramount importance in designing diagnostic and therapeutic agents for cancer. In this respect, nanocarriers have gained enormous popularity because of their attainable multifunctional features, as well as tumo...
S-EPMC5618790 | biostudies-literature
UnknownInhibiting EZH2 complements steroid effects in Duchenne muscular dystrophy.
Duchenne muscular dystrophy (DMD) is a devastating X-linked disorder caused by dystrophin gene mutations. Despite recent advances in understanding the disease etiology and applying emerging treatment methodologies, glucocorticoid derivatives remain the only general therapeutic option that can slow d...
S-EPMC11908487 | biostudies-literature
UnknownEnhancement of target specificity of CRISPR-Cas12a by using a chimeric DNA-RNA guide.
The CRISPR-Cas9 system is widely used for target-specific genome engineering. CRISPR-Cas12a (Cpf1) is one of the CRISPR effectors that controls target genes by recognizing thymine-rich protospacer adjacent motif (PAM) sequences. Cas12a has a higher sensitivity to mismatches in the guide RNA than doe...
S-EPMC7470973 | biostudies-literature
UnknownFluorine-free binder-based dry thick electrodes with Parafilm<sup>®</sup> M toward sustainable and efficient battery manufacturing.
Dry electrodes are being actively developed for sustainable and efficient battery manufacturing. Currently, polytetrafluoroethylene binders dominate dry processes, raising concerns about high fluorine content regarding restrictions on per- and polyfluoroalkyl substances. Moreover, the poor adhesion ...
S-EPMC12708863 | biostudies-literature
UnknownComparison between norepinephrine plus epinephrine and norepinephrine plus vasopressin after return of spontaneous circulation in patients with out-of-hospital cardiac arrest.
There is insufficient evidence regarding the use of second-line vasopressors following norepinephrine administration in the post-resuscitation management of patients with out-of-hospital cardiac arrest (OHCA). Therefore, this study aimed to investigate the survival outcomes between norepinephrine pl...
S-EPMC12008422 | biostudies-literature
UnknownFactors associated with shock-refractory prehospital cardiac arrest.
A significant number of out-of-hospital cardiac arrest (OHCA) patients experience refractory ventricular arrhythmias despite prompt defibrillation. These refractory arrhythmias are associated with poor clinical outcomes, underscoring the need to investigate improved management strategies. Therefore,...
S-EPMC12361564 | biostudies-literature
UnknownLaparoscopic vs Open Distal Gastrectomy for Locally Advanced Gastric Cancer: 5-Year Outcomes of the KLASS-02 Randomized Clinical Trial.

Importance

The long-term safety of laparoscopic distal gastrectomy for locally advanced gastric cancer (AGC) remains uncertain given the lack of 5-year follow-up results.

Objective

To compare the 5-year follow-up results in patients with clinically AGC enrolled in the Korean Laparoend...
S-EPMC9301593 | biostudies-literature
UnknownAssociation between the body mass index and outcomes of patients resuscitated from out-of-hospital cardiac arrest: a prospective multicentre registry study.

Background

The effects of the body mass index (BMI) on outcomes of patients resuscitated from cardiac arrest are controversial. Therefore, the current study investigated the association between the BMI and the favourable neurologic outcomes and survival to discharge of patients resuscitated ...
S-EPMC7842019 | biostudies-literature
UnknownMeta-analysis of genome-wide association studies identifies multiple lung cancer susceptibility loci in never-smoking Asian women.
Genome-wide association studies (GWAS) of lung cancer in Asian never-smoking women have previously identified six susceptibility loci associated with lung cancer risk. To further discover new susceptibility loci, we imputed data from four GWAS of Asian non-smoking female lung cancer (6877 cases and ...
S-EPMC4731021 | biostudies-literature
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