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TranscriptomicsAnalysis of temporal mRNA expression changes in cultured keratinocytes from Casp-8F/M-bM-^@M-^SK5-Cre and Casp-8F/+K5-Cre mice
Expression of enzymatically inactive caspase-8, or deletion of caspase-8 from basal epidermal keratinocytes, triggers chronic skin inflammation in mice. Unlike similar inflammation resulting from arrest of NF-kB activation in the epidermal cells, the effect induced by caspase-8 deficiency did not de...
ORGANISM(S): Mus musculus 
2009-07-29 | E-GEOD-17345 | biostudies-arrayexpress
UnknownProduction of authentic SARS-CoV M(pro) with enhanced activity: application as a novel tag-cleavage endopeptidase for protein overproduction.
Not available
S-EPMC7094453 | biostudies-literature
UnknownDifferential Vpu-Mediated CD4 and Tetherin Downregulation Functions among Major HIV-1 Group M Subtypes.
Not available
S-EPMC7343213 | biostudies-literature
TranscriptomicsLncRNA-dependent mechanisms of androgen receptor-regulated gene activation programs [ChIRP-seq]
While thousands of long non-coding RNAs (lncRNAs) are expressed in higher eukaryotes, the potential regulatory roles of lncRNAs in regulated gene transcription programs remain rather poorly understood. Here, we report that two lncRNAs highly overexpressed in aggressive prostate cancer, PRNCR1 and PC...
ORGANISM(S): Homo sapiens 
2013-08-15 | E-GEOD-47804 | biostudies-arrayexpress
UnknownSynthesis and evaluation of bisbenzylidenedioxotetrahydrothiopranones as activators of endoplasmic reticulum (ER) stress signaling pathways and apoptotic cell death in acute promyelocytic leukemic cells.
Not available
S-EPMC4216202 | biostudies-literature
GenomicsIdentify trimethylation marks from embryonic calvaria cell gene promoter regions from maternal high fat or control diet dams using H3K27me3 ChIP-Seq.
Genes with increased H3K27me3 marks in their promoters were found in mice embryonic calvaria cells using H3K27me3 ChIP-Seq. Recent data suggests that in animals and humans that a maternal diet high in fat leads to poor bone growth and development in offspring. Genes with increased H3K27me3 epigeneti...
ORGANISM(S): Mus musculus 
2022-05-31 | E-MTAB-11713 | biostudies-arrayexpress
GenomicsIdentify acetylation marks from embryonic calvaria cell gene promoter regions from maternal high fat or control diet dams using H3K27ac ChIP-Seq.
Genes with increased H3K27ac marks in their promoters were found in mice embryonic calvaria cells using H3K27ac ChIP-Seq. Recent data suggests that in animals and humans that a maternal diet high in fat leads to poor bone growth and development in offspring. Genes with increased H3K27ac epigenetic m...
ORGANISM(S): Mus musculus musculus 
2022-05-31 | E-MTAB-11712 | biostudies-arrayexpress
GenomicsIdentify acetylation marks in adult mouse L4 vertebrae gene promoter regions from maternal high fat diet dams using H3K27ac ChIP-Seq
Genes with increased H3K27ac marks in their promoters were found in adult mice L4 vertebrae from mice using H3K27ac ChIP-Seq. Recent data suggests that in animals and humans that a maternal diet high in fat leads to poor bone growth and development in offspring. Genes with increased H3K27ac epigenet...
ORGANISM(S): Mus musculus 
2022-05-31 | E-MTAB-11718 | biostudies-arrayexpress
Genomics"Drug-seq": An Approach to Identify the Genomic Targets of Chemicals Identified by Functional Phenotypic Screens [Drug-seq]
Here we report an approach that has permitted us to uncover the sites and mechanisms of action of a drug, referred to as SD70, initially identified by phenotypic screening for inhibitors of ligand and genotoxic stress-induced translocations in prostate cancer cells. Based on synthesis of a derivatiz...
ORGANISM(S): Homo sapiens 
2014-07-01 | E-GEOD-55901 | biostudies-arrayexpress
ModelsLiu2023 - Acinetobacter baumannii growth inhibition prediction with Deep Learning
This model is a Chemprop neural network trained with a growth inhibition dataset. Authors screened ~7,500 molecules for those that inhibited the growth of A. baumannii in vitro. They discovered abaucin, an antibacterial compound with narrow-spectrum activity against A. baumannii. Model Type: Predic...
2024-05-28 | MODEL2405080001 | BioModels
Machine Learning Model FAIR-AIML Ersilia 
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