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MetabolomicsUrine metabolomics phenotyping and urinary biomarker exploratory in mild cognitive impairment and Alzheimer's disease.

INTRODUCTION Alzheimer's disease is a prevalent disease with a heavy global burden and is suggested to be a metabolic disease in the brain in recent years. The metabolome is considered to be the most promising phenotype which reflects changes in genetic, transcript, and protein ...

2024-01-11 | MTBLS8662 | MetaboLights
ProteomicsO-GlcNAcylation of RPA2 at S4/S8 antagonizes phosphorylation and regulates checkpoint activation during replication stress
O-linked N-acetylglucosamine (O-GlcNAc) is the only mono-saccharide modification occurring in the cytoplasm, nucleus and mitochondria. Recent advent of the mass spectrometry technology has enabled identification of abundant O-GlcNAc transferase (OGT) substrates in diverse biological processes, such ...
ORGANISM(S): Homo Sapiens 
2024-06-21 | PXD053321 |
ProteomicsIntegrated Analysis of Proteomics and Metabolomics in Infantile Epileptic Spasms Syndrome
Objective: This study aims to investigate the pathogenic mechanisms of IESS, utilizing metabolomics and proteomics analyses to uncover potential biomarkers for the disease, thereby providing new insights for diagnostic and therapeutic strategies. Methods: Cerebrospinal fluid samples from 6 IESS pati...
ORGANISM(S): Homo Sapiens 
2024-12-23 | PXD059204 |
ProteomicsO-GlcNAcase SUMOylation studies identify the SUMO-code in chaperone-mediated autophagy
O-GlcNAcase (OGA) is the sole eraser for the intracellular O-linked N-acetylglucosamine (O-GlcNAc). OGA has many roles in diverse processes, such as cancer and embryonic stem cells, but its exact regulating mechanism is far from understood. Herein we studied small ubiquitin-like modifier (SUMO) modi...
ORGANISM(S): Homo Sapiens 
2024-10-13 | PXD056772 |
ProteomicsLC-MS/MS identification of MAVS-interacting proteins
The nanoLC-MS/MS experiments were performed on a Q Exactive mass spectrometer (Thermo Scientific) in data-dependent mode, which allowed MS data acquisition at a high resolution of 70,000 (m/z 200) across an m/z range of 300–1600. The raw data from Q Exactive analysis were analyzed with Proteome Disc...
ORGANISM(S): Homo Sapiens 
2023-03-27 | PXD041140 |
ProteomicsAD-MCI-CN proteomic data (LFQ, DDA)
This data included proteomic data of 57 Alzheimer's disease patients, 43 mild cognitive patients and 62 cognitively normal controls.
ORGANISM(S): Homo Sapiens 
2023-08-18 | PXD044672 |
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