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TranscriptomicsVariation in chromatin accessibility in human kidney cancer links H3K36 methyltransferase loss with widespread RNA processing defects
Comprehensive sequencing of human cancers has identified recurrent mutations in genes encoding chromatin regulatory proteins. For clear cell renal cell carcinoma (ccRCC), three of the five commonly mutated genes encode the chromatin regulators PBRM1, SETD2, and BAP1. How these mutations alter the ch...
ORGANISM(S): Homo sapiens 
2013-10-17 | E-MTAB-1936 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of pancreatic islets in BioBreeding rats
Like humans, the NOD mouse and other diabetes susceptible rat strains, T1D in BB rats is dependent on the major histocompatibility complex (MHC, insulin dependent diabetes mellitus locus 1, Iddm1) located on chromosome 20. In rats this is the HLA-DQB1 homologue RT1-B, specifically the RT1u haplotype...
ORGANISM(S): Rattus norvegicus 
2010-02-21 | E-GEOD-20214 | biostudies-arrayexpress
TranscriptomicsTemporal Gene Expression Profiling during Rat Femoral Marrow Ablation-Induced Intramembranous Bone Regeneration
Enhanced understanding of differential gene expression and biological pathways associated with distinct phases of intramembranous bone regeneration following femoral marrow ablation surgery will improve future advancements regarding osseointegration of joint replacement implants, biomaterials design...
ORGANISM(S): Rattus norvegicus 
2010-10-12 | E-GEOD-22321 | biostudies-arrayexpress
GenomicsA role for Widely Interspaced Zinc finger (WIZ) in retention of the G9a methyltransferase on chromatin
G9a and GLP lysine methyltransferases form a heterodimeric complex that is responsible for the bulk of cellular mono- and di-methylation on histone H3 lysine 9 (H3K9me1/me2). Widely Interspaced Zinc finger (WIZ) associates with the G9a/GLP protein complex, but its role in lysine methylation is poor...
ORGANISM(S): Homo sapiens 
2015-09-03 | E-GEOD-67317 | biostudies-arrayexpress
GenomicsNINDS-Genome-Wide Genotyping in Parkinson's Disease: First Stage Analysis and Public Release of Data

Epidemiological studies have estimated a cumulative prevalence of PD of greater than 1 per thousand. When prevalence is limited to senior populations, this proportion increases nearly 10-fold. The estimated genetic risk ratio for PD is approximately 1.7 (70% increased risk for PD if a sibling...

phs000089.v3.p2 | EGA
GenomicsCholesterol and Pharmacogenetics (CAP) Study

The Cholesterol and Pharmacogenetics Study was a 6-week open label, non-randomized study of 40mg/day simvastatin treatment in 944 African-American and Caucasian men and women. Plasma lipid and lipoprotein were measured on two occasions prior to treatment and at 4 and 6 weeks of treatment. The stu...

phs000481.v1.p1 | EGA
Genomicsena-DATASET-PICR-17-03-2014-12:03:29:405-517 - samples
Whole exome sequencing of 41 melanomas and normal DNA from Braf mutant mice: 15 tumours from UV exposed mice, 15 tumours from non-exposed mice and 11 from UV exposed, sunscreen-protected mice.
EGAD00001000775 | EGA
GenomicsWhole Exome Sequencing of cohorts of Mutant Braf mouse model melanoma DNA and germline DNA.
Whole Exome Sequencing of cohorts of Mutant Braf mouse model melanoma DNA and germline DNA. The cohorts are (1) Mutant Braf mouse model melanomas, (2) Mutant Braf mouse model melanomas from UVR exposed mice and (3) Mutant Braf mouse model melanomas from UVR exposed, sunscreen protected mice.
EGAS00001000729 | EGA
UnknownLack of AtMC1 catalytic activity triggers autoimmunity dependent on NLR stability
Not available
S-SCDT-10_1038-S44319-025-00426-4 | biostudies-other
UnknownLoss of CTLH component MAEA impairs DNA repair and replication and leads to developmental delay
Not available
S-SCDT-10_1038-S44321-025-00352-X | biostudies-other
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