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TranscriptomicsGene expression data of cultured primary microglia from neonatal control and Cstb-/- mice.
Cystain B (Cstb) is a ubiquitously expressed cysteine protease inhibitor and mutations of the CSTB gene lead to the neurodegenerative disease progressive myoclonus epilepsy of Unverricht-Lundorg type (EPM1). We are interested in the microglia-specific, Cstb-dependent gene-expression changes in mice ...
ORGANISM(S): Mus musculus 
2016-06-29 | E-GEOD-64823 | biostudies-arrayexpress
TranscriptomicsGene expression alterations in the cerebellum and granule neurons of Cstb-/- mouse are associated with early synaptic changes and inflammation
Progressive myoclonus epilepsy of Unverricht-Lundborg type (EPM1) is an inherited neurodegenerative disease with myoclonus, seizures and ataxia, caused by the mutations in cystatin B (CSTB) gene. In an approach towards understanding the molecular basis of pathogenic events in EPM1 we have utilized t...
ORGANISM(S): Mus musculus 
2014-03-03 | E-GEOD-47516 | biostudies-arrayexpress
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