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MetabolomicsCTH exacerbates Helicobacter pylori immunopathogenesis by promoting macrophage metabolic remodeling and activation
Macrophages play a crucial role in the inflammatory response to the human stomach pathogen Helicobacter pylori, which infects half of the world's population and causes gastric cancer. Recent studies have highlighted the importance of macrophage immunometabolism in their activation state and function...
2022-06-14 | MTBLS2851 | MetaboLights
GenomicsDe novo DNA methylation by DNA Methyltransferase 3a controls early effector CD8+ T cell fate decisions following activation
DNMT3a is a de novo DNA methyltransferase expressed robustly after T cell activation that regulates plasticity of CD4+ T cell cytokine expression. Here we show that DNMT3a is critical for directing early CD8+ T cell effector and memory fate decisions. While effector function of DNMT3a knockout T cel...
ORGANISM(S): Mus musculus 
2016-08-20 | E-GEOD-85823 | biostudies-arrayexpress
UnknownUnlike catalyzing error-free bypass of 8-oxodGuo, DNA polymerase λ is responsible for a significant part of Fapy·dG-induced G → T mutations in human cells.
Not available
S-EPMC4630799 | biostudies-literature
UnknownImpact of AGT rs5050(T>G) variants on associations between estradiol and angiotensinogen levels: Multi-Ethnic Study of Atherosclerosis (MESA).
Not available
S-EPMC12755761 | biostudies-literature
UnknownMyocardial remodeling is controlled by myocyte-targeted gene regulation of phosphodiesterase type 5.
Not available
S-EPMC3036840 | biostudies-literature
UnknownIncreased Herpes simplex virus 1, Toxoplasma gondii and Cytomegalovirus antibody concentrations in severe mental illness.
Not available
S-EPMC11655861 | biostudies-literature
MetabolomicsNQO1 protects obese mice through improvements in glucose and lipid metabolism.
Chronic nutrient excess leads to metabolic disorders and insulin resistance. Activation of stress-responsive pathways via Nrf2 activation contributes to energy metabolism regulation. Here, inducible activation of Nrf2 in mice and transgenesis of the Nrf2 target, NQO1, conferred protection from diet-...
2024-05-23 | MTBLS2085 | MetaboLights
UnknownCardiac troponin I Pro82Ser variant induces diastolic dysfunction, blunts β-adrenergic response, and impairs myofilament cooperativity.
Not available
S-EPMC4297775 | biostudies-literature
UnknownEpigenetic regulators of clonal hematopoiesis control CD8 T cell stemness during immunotherapy.
Not available
S-EPMC11697317 | biostudies-literature
UnknownIdentifying the localization and exploring a functional role for Gprc5c in the kidney.
Not available
S-EPMC5893170 | biostudies-literature
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