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TranscriptomicsTranscription profiling of human ER+ BrC cells with and without estradiol in both cell cultures and xenografts
We generated DNA microarray based gene expression profiles from three estrogen receptor a (ERa) positive breast cancer cell lines stimulated by 17Ã?-estradiol (E2) in vitro over a time course, as well as from MCF-7 cells grown as xenografts in ovariectomized athymic nude mice with E2 supplementation...
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-3834 | biostudies-arrayexpress
TranscriptomicsCOUP-TFII regulates human endometrial stromal genes involved in inflammation
Although the function of COUP-TFII in uterine decidualization has been described in mice, its role in the human uterus remains unknown.To interrogate the role of COUP-TFII in human endometrial function, we utilized a siRNA-mediated loss of function approach in primary human endometrial stromal cells...
ORGANISM(S): Homo sapiens 
2014-01-07 | E-GEOD-47052 | biostudies-arrayexpress
TranscriptomicsTumor grafts derived from patients with head and neck squamous carcinoma.
Head and neck squamous cell carcinoma (HNSCC) is a deadly and disfiguring disease for which better systemic therapy is desperately needed. The development of new therapies for HNSCC and the understanding of its biology both depend upon clinically relevant animal models. An increasingly promising x...
ORGANISM(S): Homo sapiens 
2013-10-28 | E-GEOD-45153 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human three different ER+ breast cancer cell lines grown in the presence and absence of estrogen to identify candidate genes involved in estrogen stimulated breast cancer growth
Three human ER+ breast cancer cell lines--MCF-7, T47-D, BT-474--grown with or without estradiol (E2). Experiment Overall Design: We analyzed biological duplicates of each cell line grown in the presence or absence of estrogen, 12 arrays in all.
ORGANISM(S): Homo sapiens 
2007-11-11 | E-GEOD-3529 | biostudies-arrayexpress
TranscriptomicsGene expression signature reflects differentiation differences rather than telomere maintenance mechanism
A gene expression signature purporting to distinguish between telomerase and ALT immortalization has recently been described (Lafferty-Whyte et al., 2009). This was obtained as the intersection of two independent signatures, one obtained from cell lines and the other from a panel of liposarcomas, w...
ORGANISM(S): Homo sapiens 
2010-03-06 | E-GEOD-20559 | biostudies-arrayexpress
UnknownGenomic characterization of novel Neisseria species.
Not available
S-EPMC6760525 | biostudies-literature
TranscriptomicsLKB1 modulates lung cancer differentiation and metastasis
Inherited mutation in LKB1 results in the Peutz-Jeghers syndrome (PJS), characterized by intestinal hamartomas and a modestly increased frequency of gastrointestinal and breast cancer1. Somatic inactivation of LKB1 occurs in human lung adenocarcinoma2-4, but its tumor suppressor role in this tissue ...
ORGANISM(S): Homo sapiens 
2007-08-28 | E-GEOD-6135 | biostudies-arrayexpress
UnknownGenetic studies of plasma analytes identify novel potential biomarkers for several complex traits.
Not available
S-EPMC4698720 | biostudies-literature
UnknownPerforming Sparse Regularization and Dimension Reduction Simultaneously in Multimodal Data Fusion.
Not available
S-EPMC6618346 | biostudies-literature
UnknownPrediction and Classification of Alzheimer's Disease Based on Combined Features From Apolipoprotein-E Genotype, Cerebrospinal Fluid, MR, and FDG-PET Imaging Biomarkers.
Not available
S-EPMC6805777 | biostudies-literature
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