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ProteomicsA novel small molecule that induces cytotoxicity in lung cancer cells inhibits disulfide reductases GSR and TXNRD1
Phenotype-based screening can identify unique small molecules that elicit a desired cellular response, but additional approaches are required to characterize their targets and mechanisms of action. Here we show that a compound termed LCS3, which selectively impairs the growth of human lung adenocarc...
ORGANISM(S): Homo sapiens (Human) 
2022-04-04 | PXD030294 | Pride
Lcs3 Thermal proteome profiling 
UnknownConsistency of pressure injury documentation across interfacility transfers.
Not available
S-EPMC6690176 | biostudies-literature
UnknownEvaluation of the Present-on-Admission Indicator among Hospitalized Fee-for-Service Medicare Patients with a Pressure Ulcer Diagnosis: Coding Patterns and Impact on Hospital-Acquired Pressure Ulcer Rates.
Not available
S-EPMC6056601 | biostudies-literature
UnknownMutational Spectrum, Copy Number Changes, and Outcome: Results of a Sequencing Study of Patients With Newly Diagnosed Myeloma.
Not available
S-EPMC6485456 | biostudies-literature
ProteomicsProteomics reveals a fibre-type specific mitochondrial remodelling with moderate- but not very high-intensity training
Methods for studying mitochondrial adaptations in skeletal muscle have mostly used whole-muscle samples, where results may be confounded by the presence of a mixture of type I and II skeletal muscle fibres. In this project, we utilised the latest Mass spectrometry (MS) techniques to provide new insi...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD036010 | Pride
Exercise Proteomics Training Single fibre Fibre type 
UnknownA molecular profile of cocaine abuse includes the differential expression of genes that regulate transcription, chromatin, and dopamine cell phenotype.
Not available
S-EPMC4104338 | biostudies-literature
TranscriptomicsA molecular profile of chronic cocaine abuse includes differential expression of genes regulating transcription, chromatin and dopamine cell phenotype
Midbrain dopamine (DA)-synthesizing neurons play a key role in the addiction process, providing a compelling rationale for determining drug-induced molecular changes arising in these cells. This microarray-based study determined the profiles of midbrain gene expression in chronic cocaine abusers (n ...
ORGANISM(S): Homo sapiens 
2014-04-01 | E-GEOD-54839 | biostudies-arrayexpress
UnknownRisky business: linking Toxoplasma gondii infection and entrepreneurship behaviours across individuals and countries.
Not available
S-EPMC6083268 | biostudies-literature
UnknownPre-existing conditions in Hispanics/Latinxs that are COVID-19 risk factors.
Not available
S-EPMC7879099 | biostudies-literature
ProteomicsA novel small molecule that induces cytotoxicity in lung cancer cells inhibits disulfide reductases GSR and TXNRD1
High-throughput phenotype-based screening of large libraries of novel compounds without known targets can identify small molecules that elicit a desired cellular response, but additional approaches are required to find and characterize their targets and mechanisms of action. Here we show that a comp...
ORGANISM(S): Homo sapiens (Human) 
2022-02-23 | PXD027228 | Pride
Lung cancer Thermal proteome profiling Lcs3-sensitive luad cells 
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