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ProteomicsPyruvate-supported flux through medium chain ketothiolase promotes mitochondrial lipid tolerance in cardiac and skeletal muscles
Even-chain acylcarnitine (AC) metabolites, most of which are generated as byproducts of incomplete fatty acid oxidation (FAO), are viewed as biomarkers of mitochondrial lipid stress attributable to one or more metabolic bottlenecks in the beta-oxidation pathway. The origins and functional implicatio...
ORGANISM(S): Mus Musculus (mouse) 
2023-04-14 | PXD040326 | JPOST Repository
ProteomicsKetone flux through BDH1 supports metabolic remodeling of skeletal and cardiac muscles in response to intermittent time-restricted feeding
Time-restricted feeding (TRF) has gained attention as a dietary regimen that promotes metabolic health. This study sought to determine if ketone flux in skeletal and cardiac muscles plays an essential role in conferring the health benefits of an intermittent TRF (iTRF) schedule. Notably, we found th...
ORGANISM(S): Mus Musculus (mouse) 
2024-02-09 | PXD047114 | JPOST Repository
TranscriptomicsMAP3K4/CBP Regulated H2B acetylation Controls Epithelial-Mesenchymal Transition in Trophoblast Stem Cells
Epithelial stem cells self-renew while maintaining multipotency, but the dependence of stem cell properties on maintenance of the epithelial phenotype is unclear. We previously showed that trophoblast stem (TS) cells lacking the protein kinase MAP3K4 maintain properties of both stemness and epitheli...
ORGANISM(S): Mus musculus 
2011-05-27 | E-GEOD-27883 | biostudies-arrayexpress
ProteomicsMetformin Impairs Intestinal Fructose Metabolism
Objective: To investigate the effects of metformin on intestinal carbohydrate metabolism in vivo. Method: Male mice preconditioned with a high-fat, high-sucrose diet were treated orally with metformin or a control solution for two weeks. Fructose metabolism, glucose production from fructose, and p...
ORGANISM(S): Mus Musculus (mouse) 
2024-04-27 | PXD041833 | JPOST Repository
TranscriptomicsDetecting novel low-abundant transcripts in Drosophila
Increasing evidence suggests that low-abundant transcripts may play fundamental roles in biological processes. In an attempt to estimate the prevalence of low-abundant transcripts in eukaryotic genomes, we performed a transcriptome analysis in Drosophila using the SAGE technique. We collected 244,31...
ORGANISM(S): Drosophila melanogaster 
2005-06-03 | E-GEOD-2347 | biostudies-arrayexpress
UnknownPatient-Level Pooled Analysis of Ultrasound Renal Denervation in the Sham-Controlled RADIANCE II, RADIANCE-HTN SOLO, and RADIANCE-HTN TRIO Trials.
Not available
S-EPMC9975919 | biostudies-literature
GenomicNIA - Late Onset Alzheimer's Disease and National Cell Repository for Alzheimer's Disease Family Study: Genome-Wide Association Study for Susceptibility Loci

Alzheimer disease is the most common neurodegenerative disorder of the elderly affecting an estimated five million Americans. Genetic factors contribute to the risk for disease with heritability estimates ranging from 57% to 79%. More than a decade ago, the ε4 variant of APOE was identified ...

phs000168 | dbGaP
UnknownEffects of Renal Denervation vs Sham in Resistant Hypertension After Medication Escalation: Prespecified Analysis at 6 Months of the RADIANCE-HTN TRIO Randomized Clinical Trial.
Not available
S-EPMC9647563 | biostudies-literature
UnknownGlutamine deprivation alters the origin and function of cancer cell exosomes
Not available
S-SCDT-EMBOJ-2019-103009 | biostudies-other
UnknownEndovascular Ultrasound Renal Denervation to Treat Hypertension: The RADIANCE II Randomized Clinical Trial.
Not available
S-EPMC9975904 | biostudies-literature
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