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TranscriptomicsAltered gene expression in Werner & Bloom syndromes is associated with sequences having G-quadruplex forming potential
The human Werner and Bloom syndromes (WS and BS) are caused by deficiencies in the WRN and BLM RecQ helicases, respectively. WRN, BLM and their S. cerevisiae homologue Sgs1, are particularly active in vitro in unwinding G-quadruplex DNA (G4-DNA), a family of non-canonical nucleic acid structures fo...
ORGANISM(S): Homo sapiens 
2009-12-09 | E-GEOD-19205 | biostudies-arrayexpress
TranscriptomicsExpression profiles of amniotic fluid from human fetuses with Down syndrome and euploid controls
In order to characterize the differences between second trimester Down syndrome (DS) and euploid fetuses, we compared gene expression in uncultured amniotic fluid supernatant samples. We identified individually differentially expressed genes via paired t-tests in the matched samples, and a set of di...
ORGANISM(S): Homo sapiens 
2009-05-21 | E-GEOD-16176 | biostudies-arrayexpress
TranscriptomicsLoss of the DNA methyltransferase MET1 induces H3K9 hypermethylation at PcG target genes in Arabidopsis, and relocation of H3K27 trimethylation to transposons [RNA-seq]
Dimethylation of histone H3 lysine 9 (H3K9m2) and trimethylation of histone H3 lysine 27 (H3K27m3) are two hallmarks of transcriptional repression in many organisms. In Arabidopsis thaliana, H3K27m3 is targeted by Polycomb Group (PcG) proteins and is associated with silent protein coding genes, whil...
ORGANISM(S): Arabidopsis thaliana 
2016-06-22 | E-GEOD-83607 | biostudies-arrayexpress
UnknownG-ruption: the third international meeting on G-quadruplex and G-assembly.
Not available
S-EPMC3707400 | biostudies-literature
TranscriptomicsLoss of the DNA methyltransferase MET1 induces H3K9 hypermethylation at PcG target genes in Arabidopsis, and relocation of H3K27 trimethylation to transposons.
Dimethylation of histone H3 lysine 9 (H3K9m2) and trimethylation of histone H3 lysine 27 (H3K27m3) are two hallmarks of transcriptional repression in many organisms. In Arabidopsis thaliana, H3K27m3 is targeted by Polycomb Group (PcG) proteins and is associated with silent protein coding genes, whil...
ORGANISM(S): Arabidopsis thaliana 
2013-03-02 | E-GEOD-37075 | biostudies-arrayexpress
TranscriptomicsLoss of the DNA methyltransferase MET1 induces H3K9 hypermethylation at PcG target genes in Arabidopsis, and relocation of H3K27 trimethylation to transposons [array]
Dimethylation of histone H3 lysine 9 (H3K9m2) and trimethylation of histone H3 lysine 27 (H3K27m3) are two hallmarks of transcriptional repression in many organisms. In Arabidopsis thaliana, H3K27m3 is targeted by Polycomb Group (PcG) proteins and is associated with silent protein coding genes, whil...
ORGANISM(S): Arabidopsis thaliana 
2016-06-22 | E-GEOD-83606 | biostudies-arrayexpress
UnknownJNJ-78306358, a first-in-class bispecific T cell engaging antibody targeting CD3 and HLA-G.
Not available
S-EPMC11889666 | biostudies-literature
UnknownStructural basis for recognition of the central conserved region of RSV G by neutralizing human antibodies.
Not available
S-EPMC5856423 | biostudies-literature
UnknownCytotoxic G-rich oligodeoxynucleotides: putative protein targets and required sequence motif.
Not available
S-EPMC1935016 | biostudies-literature
ProteomicsAbsolute quantification of human milk caseins and the whey/casein ratio during the first year of lactation
Whey proteins and caseins in breast milk provide bioactivities and also have different amino acid composition. Accurate determination of these two major protein classes will therefore provide a better understanding of human milk composition and function and also aid in developing improved infant for...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-06-23 | MSV000081195 | MassIVE
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