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TranscriptomicsThe NIH Human Pluripotent Stem Cell Database
This SuperSeries is composed of the following subset Series: GSE32923: The NIH Human Pluripotent Stem Cell Database (Agilent, mRNA) GSE33789: The NIH Human Pluripotent Stem Cell Database (Affymetrix, mRNA) GSE34199: The NIH Human Pluripotent Stem Cell Database (Agilent, miRNA) GSE34869: The NIH Huma...
ORGANISM(S): Homo sapiens 
2012-10-31 | E-GEOD-34200 | biostudies-arrayexpress
TranscriptomicsDifferentiation of human fetal multipotential neural progenitor cells to astrocytes reveals susceptibility factors for JC Virus
Viral infections of the CNS are of increasing concern, especially among immunocompromised populations. Rodent models are often inappropriate for studies of CNS infection, as many viruses, including JC Virus (JCV) and HIV, cannot replicate in rodent cells. Consequently, human fetal brain-derived mult...
ORGANISM(S): Homo sapiens 
2013-04-09 | E-GEOD-43794 | biostudies-arrayexpress
TranscriptomicsInduction of IL-17+ T-cells by HIV-Tat protein is mediated via Vascular Endothelial Growth Factor Receptor-2
Anti-retroviral therapy (ART) has transformed human immunodeficiency virus (HIV) infection from a fatal illness to a chronic condition by controlling viral replication and restoring immune function. However, chronic T-cell activation can be observed in 20-35% of individuals on ART, resulting in an i...
ORGANISM(S): Homo sapiens 
2013-08-02 | E-GEOD-44460 | biostudies-arrayexpress
TranscriptomicsClonal Immortalized Human Glial Cell Lines Support Varying Levels of JC Virus Infection due to Differences in Cellular Gene Expression
JC virus (JCV) is a ubiquitous human polyomavirus that causes the demyelinating disease Progressive Multifocal Leukoencephalopathy (PML). JCV replicates in limited cell types in culture, predominantly in human glial cells. Thus, productive JCV infection is an indicator of the host cell transcription...
ORGANISM(S): Homo sapiens 
2013-10-17 | E-GEOD-45639 | biostudies-arrayexpress
TranscriptomicsComparison of the molecular profiles of human embryonic and isogenic induced pluripotent stem cells. [Agilent]
Many studies have compared the genetic and epigenetic profiles of human induced pluripotent stem cells (hiPSCs) to human embryonic stem cells (hESCs) and yet the picture remains unclear. To address this, we derived a population of neural precursor cells (NPCs) from the H1 (WA01) hESC line and genera...
ORGANISM(S): Homo sapiens 
2014-01-01 | E-GEOD-51561 | biostudies-arrayexpress
TranscriptomicsRetinoid X Receptor activation reverses the age-related deficiency in myelin debris phagocytosis and enhances remyelination
The efficiency of central nervous system (CNS) remyelination declines with age. This is in part due to an age-associated decline in the phagocytic removal of myelin debris, which contains inhibitors of oligodendrocyte progenitor cell differentiation. In this study we show that expression of genes i...
ORGANISM(S): Homo sapiens 
2015-11-04 | E-GEOD-66988 | biostudies-arrayexpress
TranscriptomicsThe NIH Human Pluripotent Stem Cell Database (Agilent, mRNA)
To better understand the extent to which induced pluripotent stem cells (iPSCs) faithfully recapitulate the characteristics of embryonic stem cells (ESCs) under (undiff)erentiated condition, KSR condition and FBS condition and how both compare to somatic tissues under these conditions, we employed w...
ORGANISM(S): Homo sapiens 
2012-10-31 | E-GEOD-32923 | biostudies-arrayexpress
TranscriptomicsThe NIH Human Pluripotent Stem Cell Database (Illumina, methylation)
Methylation profiling was performed on DNA samples matched to the RNA samples included in the NIH Human Pluripotent Stem Cell Database (Series GSE32923). Nineteen undifferentiated human embryonic stem cell lines and 5 human induced pluripotent stem cells were analyzed. Expanded descriptions of metho...
ORGANISM(S): Homo sapiens 
2012-10-31 | E-GEOD-34869 | biostudies-arrayexpress
TranscriptomicsThe NIH Human Pluripotent Stem Cell Database (Affymetrix, mRNA)
To broaden the appeal of the NIH Stem Cell Database, we analyzed a subset of undifferentiated human embryonic stem cell lines (5 lines in duplicate) on the Affymetrix platform. One standard culture protocol was used in conjunction with rigorous quality control. Expanded description of methods used a...
ORGANISM(S): Homo sapiens 
2012-10-31 | E-GEOD-33789 | biostudies-arrayexpress
TranscriptomicsThe NIH Human Pluripotent Stem Cell Database (Agilent, miRNA)
MicroRNA profiling was performed on RNA samples matched to those included in the NIH Human Pluripotent Stem Cell Database (Series GSE32923). Twenty undifferentiated human embryonic stem cell lines and 4 human tissues were analyzed. Expanded descriptions of methods used are available at: http://stemc...
ORGANISM(S): Homo sapiens 
2012-10-31 | E-GEOD-34199 | biostudies-arrayexpress
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