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TranscriptomicsThe NIH Human Pluripotent Stem Cell Database
This SuperSeries is composed of the following subset Series: GSE32923: The NIH Human Pluripotent Stem Cell Database (Agilent, mRNA) GSE33789: The NIH Human Pluripotent Stem Cell Database (Affymetrix, mRNA) GSE34199: The NIH Human Pluripotent Stem Cell Database (Agilent, miRNA) GSE34869: The NIH Huma...
ORGANISM(S): Homo sapiens 
2012-10-31 | E-GEOD-34200 | biostudies-arrayexpress
TranscriptomicsInduction of IL-17+ T-cells by HIV-Tat protein is mediated via Vascular Endothelial Growth Factor Receptor-2
Anti-retroviral therapy (ART) has transformed human immunodeficiency virus (HIV) infection from a fatal illness to a chronic condition by controlling viral replication and restoring immune function. However, chronic T-cell activation can be observed in 20-35% of individuals on ART, resulting in an i...
ORGANISM(S): Homo sapiens 
2013-08-02 | E-GEOD-44460 | biostudies-arrayexpress
TranscriptomicsDifferentiation of human fetal multipotential neural progenitor cells to astrocytes reveals susceptibility factors for JC Virus
Viral infections of the CNS are of increasing concern, especially among immunocompromised populations. Rodent models are often inappropriate for studies of CNS infection, as many viruses, including JC Virus (JCV) and HIV, cannot replicate in rodent cells. Consequently, human fetal brain-derived mult...
ORGANISM(S): Homo sapiens 
2013-04-09 | E-GEOD-43794 | biostudies-arrayexpress
TranscriptomicsMaternal immune activation by LPS selectively alters specific gene expression profiles of interneuron migration and oxidative stress in the fetus without triggering a fetal immune response.
Maternal immune activation is a risk factor for the development of schizophrenia and autism. Infections during pregnancy activate the mother's immune system and alter the fetal environment with sub-sequence effects of CNS function and behavior in the offspring, but the cellular and molecular links b...
ORGANISM(S): Rattus norvegicus 
2012-07-25 | E-GEOD-34058 | biostudies-arrayexpress
TranscriptomicsThe NIH Human Pluripotent Stem Cell Database (Illumina, snp)
Genotyping was performed on DNA samples matched to the RNA samples included in the NIH Human Pluripotent Stem Cell Database (Series GSE32923). Seventeen undifferentiated human embryonic stem cell lines and 11 human induced pluripotent stem cells were analyzed. Expanded descriptions of methods used a...
ORGANISM(S): Homo sapiens 
2012-10-31 | E-GEOD-35157 | biostudies-arrayexpress
TranscriptomicsClonal Immortalized Human Glial Cell Lines Support Varying Levels of JC Virus Infection due to Differences in Cellular Gene Expression
JC virus (JCV) is a ubiquitous human polyomavirus that causes the demyelinating disease Progressive Multifocal Leukoencephalopathy (PML). JCV replicates in limited cell types in culture, predominantly in human glial cells. Thus, productive JCV infection is an indicator of the host cell transcription...
ORGANISM(S): Homo sapiens 
2013-10-17 | E-GEOD-45639 | biostudies-arrayexpress
TranscriptomicsThe NIH Human Pluripotent Stem Cell Database (Illumina, methylation)
Methylation profiling was performed on DNA samples matched to the RNA samples included in the NIH Human Pluripotent Stem Cell Database (Series GSE32923). Nineteen undifferentiated human embryonic stem cell lines and 5 human induced pluripotent stem cells were analyzed. Expanded descriptions of metho...
ORGANISM(S): Homo sapiens 
2012-10-31 | E-GEOD-34869 | biostudies-arrayexpress
TranscriptomicsThe NIH Human Pluripotent Stem Cell Database (Agilent, cgh)
Array comparative genomic hybridization was performed on DNA samples matched to the RNA samples included in the NIH Human Pluripotent Stem Cell Database (Series GSE32923). Twenty two undifferentiated human embryonic stem cell lines were analyzed. Expanded descriptions of methods used are available a...
ORGANISM(S): Homo sapiens 
2012-10-31 | E-GEOD-35735 | biostudies-arrayexpress
TranscriptomicsThe NIH Human Pluripotent Stem Cell Database (Agilent, miRNA)
MicroRNA profiling was performed on RNA samples matched to those included in the NIH Human Pluripotent Stem Cell Database (Series GSE32923). Twenty undifferentiated human embryonic stem cell lines and 4 human tissues were analyzed. Expanded descriptions of methods used are available at: http://stemc...
ORGANISM(S): Homo sapiens 
2012-10-31 | E-GEOD-34199 | biostudies-arrayexpress
TranscriptomicsThe NIH Human Pluripotent Stem Cell Database (Affymetrix, mRNA)
To broaden the appeal of the NIH Stem Cell Database, we analyzed a subset of undifferentiated human embryonic stem cell lines (5 lines in duplicate) on the Affymetrix platform. One standard culture protocol was used in conjunction with rigorous quality control. Expanded description of methods used a...
ORGANISM(S): Homo sapiens 
2012-10-31 | E-GEOD-33789 | biostudies-arrayexpress
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