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Inherited mutation in LKB1 results in the Peutz-Jeghers syndrome (PJS), characterized by intestinal hamartomas and a modestly increased frequency of gastrointestinal and breast cancer1. Somatic inactivation of LKB1 occurs in human lung adenocarcinoma2-4, but its tumor suppressor role in this tissue ...
ORGANISM(S): Homo sapiens 
This SuperSeries is composed of the following subset Series: GSE12166: TJ411(fer-15(b26)II; age-1(hx542)II) vs. BA713(fer-15(b26)II) GSE12167: TJ1081)fer-15(b26)II; daf-16(m26)I) vs. BA713(fer-15(b26)II) GSE12168: Aging Time course Refer to individual Series
ORGANISM(S): Caenorhabditis elegans 
RNA was isolated from age-synchronous cultures of hermaphrodite worms grown at 25?C at 2, 5, 8, or 11 days of adulthood. We observed no deaths in the worm population at days 2 and 5 of adulthood, 30% at day 8 and 93% death at day 11. The aging time course was repeated four times. Groups of assays t...
ORGANISM(S): Caenorhabditis elegans 
To identify changes in gene expression in age-1 mutants, we compared expression in fer-15(b26) animals to expression in fer-15(b26); age-1(hx542) mutants. We prepared RNA from young adult fer-15(b26) mutants grown at 25?C (five samples prepared at Stanford University and six samples prepared at the...
ORGANISM(S): Caenorhabditis elegans 
To identify changes in gene expression in daf-16 mutants, we compared expression in fer-15 young adults to expression in fer-15(b26); daf-16(m26) young adults grown at 25?C. At Stanford University, four samples of fer-15 and five samples of fer-15; daf-16 animals were prepared. At the University o...
ORGANISM(S): Caenorhabditis elegans 
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