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TranscriptomicsCombined heterozygous loss of Ebf1 and Pax5 allows for T-lineage conversion of B-cell progenitors
In order to investigate how transcription factor dose impacts B-lymphocyte development, we generated mice carrying transheterozygous mutations in the Pax5 and Ebf1 genes. While combined reduction of Pax5 and Ebf1 dose had minimal impact on the development of the earliest CD19+ progenitors, these cel...
ORGANISM(S): Mus musculus 
2015-05-27 | E-GEOD-69227 | biostudies-arrayexpress
UnknownPotential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine.
Not available
S-EPMC5727343 | biostudies-literature
TranscriptomicsExpression profiling of ProB and PreB cells in Ebf1 heterozygous mouse bone marrow
Loss of one allele of Ebf1 impairs pre-B cell (B220+CD19+CD43low/negIgM-) expansion. In order to better understand the underlying cause of the reduced pre-B cell compartment in Ebf1+/- mice, we sorted pro-B (B220+CD19+CD43highIgM- ) as well as pre-B cells from Wt and Ebf1 heterozygote mutant mice an...
ORGANISM(S): Mus musculus 
2013-10-18 | E-GEOD-51385 | biostudies-arrayexpress
TranscriptomicsEbf1 heterozygosity results in increased DNA damage in pro-B cells and their synergistic transformation by Pax5 haploinsufficiency
Ebf1 is a transcription factor with documented, and dose dependent, functions in both normal and malignant B-lymphocyte development. In order to understand more about the role of Ebf1 in malignant transformation, we have investigated the impact of reduced functional Ebf1 dose on early B-cell progeni...
ORGANISM(S): Mus musculus 
2015-03-31 | E-GEOD-67415 | biostudies-arrayexpress
UnknownResponse-guided telaprevir combination treatment for hepatitis C virus infection.
Not available
S-EPMC3809077 | biostudies-literature
UnknownGlobal, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013.
Not available
S-EPMC4624264 | biostudies-literature
UnknownNational, regional, and global trends in adult overweight and obesity prevalences.
Not available
S-EPMC3543235 | biostudies-literature
UnknownThe global cardiovascular risk transition: associations of four metabolic risk factors with national income, urbanization, and Western diet in 1980 and 2008.
Not available
S-EPMC4181853 | biostudies-literature
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