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TranscriptomicsThe transcriptional repressor BLIMP1 curbs host-defenses by suppressing expression of the chemokine CCL8
The transcriptional repressor BLIMP1 is a master regulator of B and T cell differentiation. To examine the role of BLIMP1 in innate immunity we used a conditional knockout (CKO) of Blimp1 in myeloid cells and found that Blimp1 CKO mice were protected from lethal infection induced by Listeria monocyt...
ORGANISM(S): Mus musculus 
2013-12-10 | E-GEOD-53145 | biostudies-arrayexpress
TranscriptomicsThe genome of the grape powdery mildew pathogen
Powdery mildew (Erysiphe necator) is a widespread and economically important disease of grapevines. Large quantities of fungicides are used for its control, accelerating the incidence of fungicide-resistance. A shotgun approach was applied to sequence and assemble the E. necator genome of five isola...
ORGANISM(S): Vitis vinifera 
2014-12-10 | E-GEOD-58958 | biostudies-arrayexpress
TranscriptomicsATAC-seq of monocytes from patients before and after anti-malarial treatment
Patients received standardized coartem therapy. Briefly, each pill contains 20 mg of artemether and 120 mg of lumefantrine. The dose and total coarse of tablets is based on the patients body weight. Blood was drawn from patients prior to anti-malarial treatment (day 0) and after treatment (day42 for...
ORGANISM(S): Homo sapiens 
2022-04-24 | E-MTAB-11643 | biostudies-arrayexpress
TranscriptomicsComparative transcriptomics of Central Asian Vitis vinifera accessions reveals distinct defense strategies against powdery mildew
Grape powdery mildew (PM), caused by the biotrophic ascomycete Erysiphe necator, is a devastating fungal disease that affects most Vitis vinifera cultivars. We have previously identified a panel of V. vinifera accessions from Central Asia with partial resistance to PM that possess a Ren1-like local ...
ORGANISM(S): Vitis vinifera subsp. silvestris 
2015-07-20 | E-GEOD-67191 | biostudies-arrayexpress
TranscriptomicsImmune regulation by low doses of the DNA methyltransferase inhibitor 5-azacitidine in common human epithelial cancers [methylation]
Epigenetic therapy is emerging as a potential therapy for solid tumors. To investigate its mechanism of action, we performed integrative expression and methylation analysis of 63 cancer cell lines (breast, colorectal, and ovarian) after treatment with the DNA methyltransferase inhibitor 5-azacitidin...
ORGANISM(S): Homo sapiens 
2014-05-08 | E-GEOD-57342 | biostudies-arrayexpress
TranscriptomicsEffect of AZA on gene expression of multiple breast, colon, and ovarian cell lines [expression]
Epigenetic therapy is emerging as a potential therapy for solid tumors. To investigate its mechanism of action, we performed integrative expression and methylation analysis of 63 cancer cell lines (breast, colorectal, and ovarian) after treatment with the DNA methyltransferase inhibitor 5-azacitidin...
ORGANISM(S): Homo sapiens 
2014-05-08 | E-GEOD-57341 | biostudies-arrayexpress
Unknownp53 and ovarian carcinoma survival: an Ovarian Tumor Tissue Analysis consortium study.
Not available
S-EPMC10073933 | biostudies-literature
UnknownCopy Number Variants Are Ovarian Cancer Risk Alleles at Known and Novel Risk Loci.
Not available
S-EPMC9949586 | biostudies-literature
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