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TranscriptomicsSF-1 and RNF31 knockdown and forskolin treatment
The human adrenocortical carcinoma cell line NCI-H295R treated with siRNA targeting SF-1 or RNF31 with luciferase-targeting siRNA as control. Combined with forskolin treatment.
ORGANISM(S): Homo sapiens 
2012-02-01 | E-MEXP-3259 | biostudies-arrayexpress
UnknownInterleukin-1β drives NEDD8 nuclear-to-cytoplasmic translocation, fostering parkin activation via NEDD8 binding to the P-ubiquitin activating site.
Not available
S-EPMC6935243 | biostudies-literature
TranscriptomicsInterplay between AP-1 and ERalpha in regulating gene expression and proliferation networks in breast cancer cells
Estrogen receptor alpha (ERalpha) is a ligand-dependent transcription factor that plays an important role in breast cancer. Estrogen-dependent gene regulation by ERalpha can be mediated by interaction with other DNA-binding proteins, such as activator protein-1 (AP-1). The nature of such interaction...
ORGANISM(S): Homo sapiens 
2012-08-05 | E-GEOD-36586 | biostudies-arrayexpress
TranscriptomicsSupport of a bi-faceted role of ERM-NM-2 in ERM-NM-1-positive breast cancer cells.
Comparison of the basal and estrogen-induced effects on genome-wide transcription in ERM-NM-1-positive breast cancer cell lines T47D and MCF7 after lentiviral transduction with ERM-NM-2. Comparison of ERM-NM-2-transduced T47D and MCF7 cells versus respective control-transduced cells, in the presence...
ORGANISM(S): Homo sapiens 
2013-11-21 | E-GEOD-45047 | biostudies-arrayexpress
UnknownAdjuvant trastuzumab in HER2-positive breast cancer.
Not available
S-EPMC3268553 | biostudies-literature
TranscriptomicsGene expression profiling of archival tongue carcinoma and normal tongue tissue (all samples)
RNA extracted from 78 FFPE tongue samples, 62 tongue carcinomas and 16 non-malignant controls, were succesfully analysed using the whole genome DASL array to obtain gene expression profiles. Gene expression profiles were used to identify differentially expressed genes with the ultimate goal of findi...
ORGANISM(S): Homo sapiens 
2012-05-10 | E-GEOD-34105 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of archival tongue carcinoma and normal tongue tissue (subset)
RNA extracted from 78 FFPE tongue samples, 62 tongue carcinomas and 16 non-malignant controls, were succesfully analysed using the whole genome DASL array to obtain gene expression profiles. Gene expression profiles were used to identify differentially expressed genes with the ultimate goal of findi...
ORGANISM(S): Homo sapiens 
2012-05-10 | E-GEOD-34106 | biostudies-arrayexpress
TranscriptomicsGenome-wide profiling of inflammatory cistrome reveals AP-1/c-Jun as a key regulator of TNFalpha-mediated triple-negative breast cancer progression [microarray]
Triple-negative breast cancer (TNBC) represents a highly aggressive form of breast cancer with limited treatment options. Proinflammatory cytokines such as TNFalpha can facilitate tumor progression and metastasis. However, our knowledge of the molecular mechanisms underlying TNBC progression mediate...
ORGANISM(S): Homo sapiens 
2016-01-20 | E-GEOD-71915 | biostudies-arrayexpress
TranscriptomicsEDCs gene expression profile in MCF7 cells
Endocrine disrupting chemicals (EDCs) are compounds that disrupt normal hormonal signaling. Examples are Xenoestrogens (e.g BPA) and Phytoestrogens (e.g isoflavones). Comparison of EDC treated versus vehicle treated MCF7 parental cells. Each comparison in technical and biological duplicate.
ORGANISM(S): Homo sapiens 
2013-12-31 | E-GEOD-45721 | biostudies-arrayexpress
TranscriptomicsInsights into the invasiveness of triple negative breast cancer from genome-wide profiling of transcription factor AP-1 (expression)
Triple negative breast cancer (TNBC) is an aggressive clinical phenotype, and accounts for 15% to 20% of all breast cancers. The molecular determinants of malignant cell behaviors in TNBC remain largely unknown. We find that the AP-1 transcription factor component, Fra-1, is overexpressed in basal-l...
ORGANISM(S): Homo sapiens 
2014-06-30 | E-GEOD-46440 | biostudies-arrayexpress
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