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Homo sapiens (80)
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Mass Spectrometry (66)
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Instrument Platform

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N/a (1)
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2005 (1)

CHEBI ID

CHEBI:10545 (1)
CHEBI:10698 (1)
CHEBI:10725 (1)
CHEBI:10727 (1)
CHEBI:10729 (1)
CHEBI:10735 (1)
CHEBI:10986 (1)
CHEBI:11047 (1)
CHEBI:11305 (1)
CHEBI:11805 (1)
CHEBI:11851 (1)
CHEBI:11892 (1)
CHEBI:11951 (1)
CHEBI:12194 (1)
CHEBI:12387 (1)
CHEBI:128769 (1)
CHEBI:13115 (1)
CHEBI:13166 (1)
CHEBI:13170 (1)
CHEBI:132403 (1)
CHEBI:132546 (1)
CHEBI:132918 (1)
CHEBI:133091 (1)
CHEBI:133744 (1)
CHEBI:133803 (1)
CHEBI:136960 (1)
CHEBI:13705 (1)
CHEBI:137386 (1)
CHEBI:137981 (1)
CHEBI:138668 (1)

Metabolite Name

1-methyladenosine (2)
12,13-DiHOME (2)
2'-O-methyluridine (2)
2'-deoxyinosine (2)
2'-deoxyuridine (2)
2,6-dihydroxybenzoic acid (2)
5-oxoproline (2)
9,10-DiHOME (2)
Acesulfame (2)
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Beta-alanine (2)
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Citrulline (2)
N-acetylasparagine (2)
N-acetylcitrulline (2)
N-acetylglycine (2)
N-acetylhistidine (2)
N-acetylphenylalanine (2)
N-acetylputrescine (2)
N-acetyltyrosine (2)
N-methylproline (2)
O-acetylhomoserine (2)

First Public Date

2026 (2)
2025 (1)
2021 (1)

Modelling Approach

Constraint-based model (1)

Lab affiliation

Copenhagen Center for Glycomics and Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, DK-2200 Copenhagen N, Denmark (2)
Copenhagen Center for Glycomics, Departments of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen N, Denmark (2)
Department of Cellular and Molecular Medicine, University of Copenhagen (2)
King's College London, British Heart Foundation Centre, School of Cardiovascular Medicine and Sciences, London, UK (2)
University of Turku, Turku Bioscience (2)
1.Department of Molecular Biology and Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, MA 02114, USA, 2.Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA, 3.Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. (1)
Akhilesh Pandey, M.D., Ph.D. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, United States (1)
Associate Professor Glyco MS Group Copenhagen Center for Glycomics (CCG) Department of Cellular and Molecular Medicine (24.6.36) University of Copenahgen Blegdamsvej 3 2200 Copenhagen N Denmark (1)
Associate Professor Glyco MS Group Copenhagen Center for Glycomics (CCG) Department of Cellular and Molecular Medicine University of Copenahgen Blegdamsvej 3 2200 Copenhagen N Denmark (1)
Babraham Institute Cambridge, UK (1)
Biomolecular Mass Spectrometry and Proteomics Utrecht University The Netherlands (1)
Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY (1)
Charles Perkins Centre, University of Sydney (1)
Copenhagen Center for Glycomics (CCG), Department of Cellular and Molecular Medicine, University of Copenhagen, Denmark (1)
Copenhagen Center for Glycomics (CCG), Glyco-MS Group Department of Cellular and Molecular Medicine University of Copenhagen (1)
Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, University of Copenhagen (1)
Department of Biochemistry and Microbiology, L-Probe Lab Ghent University (1)
Department of Biophysics, National Institute of Mental Health and Neurosciences (NIMHANS). India. (1)
Department of Laboratory Medicine and Pathology Mayo Clinic Rochester Minnesota (1)
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA (1)
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA (1)
Department of Molecular Biology, Radboud Institute for Molecular Life Sciences (1)
Department of Molecular, Cellular & Biomedical Sciences, University of New Hampshire, Durham, NH 03824, USA Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. (1)
Department of Physiology, University of Kentucky, USA (1)
Department of Zoology, Savitribai Phule University, Pune, Maharashtra, India (1)
Department of Zoology, University of Delhi, Delhi, India (1)
Departments of Chemistry, Biological Sciences, Pathology, Microbiology and Immunology, Vanderbilt University (1)
Dept. Oncology Pathology, Karolinska Institutet, and Scilifelab, Stockholm, Sweden (1)
Dept. of Biochemistry, Universidade Federal do Parana, Curitiba-PR, Brazil (1)
Division of Biotechnology, CSIR-Institute of Himalayan Bioresource Technology, Palampur-176061, Himachal Pradesh, India (1)

IsPrivate

False (1)

Model Flag

Non Kinetic (1)

Modification

4-tetrahydrothiazine-3-carboxylic acid (2)
2x(15)N labeled L-lysine (1)
4x(2)H labeled dimethylated L-lysine (1)

Study type

Transcription profiling by array (26)
RNA-seq of coding RNA (17)
ChIP-seq (6)
Comparative genomic hybridization by array (4)
RNA-seq of non coding RNA (3)
Genotyping by array (2)
ScATAC-seq (2)
Methylation profiling by array (2)
Transcription profiling by SAGE (1)
Unknown experiment type (1)
Transcription profiling by RT-PCR (1)
ATAC-seq (1)
Other (1)
Methylation profiling by high throughput sequencing (1)
RNA-seq of total RNA (1)

Release Date

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(E)-N'-{7-Meth-oxy-spiro-[chromeno[4,3-d]thia-zole-4,1'-cyclo-hexa-n]-2-yl}-N,N-dimethyl-acetimidamide.

Not available

S-EPMC3247592 | biostudies-literature

Extensive hypoglycosylation of serum N-glycoproteins in SRD5A3 deficiency

Polyprenol reductase is an enzyme encoded by the SRD5A3 gene, which catalyzes the synthesis of dolichol from polyprenols. Dolichol serves as a carrier for glycan precursors in N-linked glycosylation or monosaccharides in O-glycosylation, C-mannosylation, and GPI anchor biosynthesis. Pathogenic varia...

ORGANISM(S): Homo sapiens (Human)

2026-06-08 | PXD053534 | Pride