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TranscriptomicsEffect of adk1 knock-out mutation on global transcription
We investigated the effects of the variation in intracellular adenylic nucleotides pools due to the absence of the adenylate kinase Adk1p on the global yeast transcriptome. In this work, global transcription analyses were combined to measurements of intracellular nucleotides pools by HPLC. Keywords:...
ORGANISM(S): Saccharomyces cerevisiae 
2008-04-17 | E-GEOD-9553 | biostudies-arrayexpress
TranscriptomicsRole of the AMP deaminase Amd1p in purines interconversion in Saccharomyces cerevisiae
In this work, we show that under specific conditions, defect in AMP deaminase activity strongly impairs yeast cell growth and we establish that AMP deaminase is required for correct balance between adenylic and guanylic nucleotides. Study of the Amd1p homologs, Yjl070p and Ybr284p, reveals that over...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-20 | E-GEOD-9557 | biostudies-arrayexpress
TranscriptomicsSilicon metabolism in diatoms
We investigated the effects of extracellular silicic acid on the whole Phaeodactylum triconutum transcriptome. In this work, global transcription analyses were combined with comparative studies of other elements, and detailed analyses of the silicon transporters. Our results provide insight on Si-se...
ORGANISM(S): Phaeodactylum tricornutum 
2009-09-29 | E-GEOD-12015 | biostudies-arrayexpress
TranscriptomicsThe Sarcoglycan complex is expressed in the cerebrovascular system and is specifically regulated by astroglial Cx30 channels
Astrocytes, the most prominent glial cell type in the brain, send specialized processes called endfeet around blood vessels and express a large molecular repertoire regulating the cerebrovascular system physiology. One of the most striking properties of astrocyte endfeet is their enrichment in gap j...
ORGANISM(S): Mus musculus 
2015-03-03 | E-GEOD-59148 | biostudies-arrayexpress
TranscriptomicsComparative analysis of single-cell and spatial Nanopore long-read methods
Alternative splicing significantly contributes to transcriptome complexity and has critical implications for cellular functions. Recent advancements in single-cell isolation and capture techniques have enabled high-throughput quantification of gene expression at single-cell resolution. Long-read seq...
ORGANISM(S): Mus musculus 
2025-08-26 | E-MTAB-15190 | biostudies-arrayexpress
ProteomicsFasting upregulates the monocarboxylate transporter Mct1 at the rat blood-brain barrier through Ppar d activation
Fasting is increasingly recognized as a potential therapeutic intervention in the field of neurology and psychiatry. However, its impact upon the blood-brain barrier (BBB), which strictly regulates the cerebral uptake of a wide range of endogenous compounds and drugs, is unknown. In this study we us...
ORGANISM(S): Cellular Organisms 
2024-08-15 | PXD044587 | JPOST Repository
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