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MetabolomicsOxidative phosphorylation is a metabolic vulnerability of endocrine therapy and palbociclib resistant metastatic breast cancers
Resistance to endocrine treatments and CDK4/6 inhibitors is considered a near-inevitability in most patients with estrogen receptor positive breast cancers (ER + BC). By genomic and metabolomics analyses of patients' tumours, metastasis-derived patient-derived xenografts (PDX) and isogenic cell line...
2023-06-27 | MTBLS3342 | MetaboLights
ProteomicsDIA of Gasdermin-D knockout and cuprizone treated mouse brain tissue
Data-independent acquisition (DIA) of four replicates of mouse brain tissue lysate for each of the four conditions Gasdermin-D WT, Gasdermin-D KO, Gasdermin-D WT treated with cuprizone, and Gasdermin-D KO treated with cuprizone.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-02-02 | MSV000091185 | MassIVE
TranscriptomicsTranscription profiling by array of yeast isolates at different time points during fermentation
Transcriptome analysis in natural Saccharomyces cerevisiae as function of fermentation stage. Strains used were the reference strain S288C, two (06L3FF02 and 06L6FF20) isolates from the Bairrada wine region, Portugal, three (Lalvin EC-1118, Lalvin ICV D254 and AEB Fermol Rouge) wine yeast obtained c...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-24 | E-MTAB-112 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA sequencing of colorectal cancer
We profile single cells from patients with colorectum cancer using Chromium 3’ and 5’ single-cell RNA-sequencing. Patients EXT001, EXT009, and EXT012 from the KUL dataset were first analyzed by Lee et al., 2020, and the raw data are available in ArrayExpress under the accession codes E-MTAB-8410 and...
ORGANISM(S): Homo sapiens 
2022-09-16 | E-MTAB-9934 | biostudies-arrayexpress
GenomicsLocalization of the Rb tumor suppressor in MEFs during reprogramming to iPS and the consequence of Rb loss on the transcriptional profile and histone landscape in these cells
The reprogramming of differentiated cells to an embryonic stem cell-like state provides a powerful system to explore fundamental mechanisms of development, including how mammalian cells establish and maintain pluripotency and long-term self-renewal capability. Based on the similarities between embry...
ORGANISM(S): Mus musculus 
2014-11-13 | E-GEOD-40594 | biostudies-arrayexpress
GenomicsIntegrative genomic profiling of hepatocellular adenomas reveals recurrent FRK activating mutations and mutational processes of malignant transformation
Hepatocellular adenomas (HCA) are benign liver tumors predominantly developed in women using oral contraception. Here, exome sequencing identified novel recurrent somatic FRK mutations that induce constitutive kinase activity, STAT3 activation and cell proliferation sensitive to Src inhibitors. We a...
EGAS00001000679 | EGA
GenomicsExome-sequencing identifies new oncogenes and tumor suppressor genes recurrently altered in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is the most common primary liver malignancy. High-resolution copy number analysis of 125 tumors of which 24 were subjected to whole-exome sequencing identified 135 homozygous deletions and 994 somatic gene mutations with predicted functional consequences. We identified...
EGAS00001000217 | EGA
TranscriptomicsIGR_Michels_PARP
Non-small cell lung cancer (NSCLC) is often treated with cisplatin (CDDP). Here, we report that two distinct poly(ADP-ribose) polymerase (PARP) inhibitors exhibited a hyperadditive combination effect with CDDP to kill NSCLC cells. A majority of CDDP-resistant cell lines and clones exhibited constitu...
ORGANISM(S): Homo sapiens 
2013-10-31 | E-MTAB-1353 | biostudies-arrayexpress
Genomicsexome_seq_hepatcell_adenomas - samples
Whole exome sequencing data from 30 donors (46 tumors and 30 non-tumoral whole exome sequencing, paired-end, HiSeq 2000, Illumina) collected by the Inserm U674, PI Jessica Zucman-Rossi - Institut National du Cancer (INCa), PI Fabien Calvo, France.
EGAD00001000737 | EGA
GenomicsEGAS00001001002 - samples
Description not provided
EGAD00001001096 | EGA
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