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TranscriptomicsGene expression profiling of novel antigen presenting cells (APC) inducing pathogenic T helper cells of lupus
In lupus autoimmunity, pathogenic IgG autoantibodies that fix complement and bind FcGammaR on inflammatory cells, are produced with help from T helper (Th1 and Th17) cells specific for peptides from nucleosomes of apoptotic cells; and these Th cells also infiltrate vital organs (1-9). Macrophages (...
ORGANISM(S): Mus musculus 
2012-06-20 | E-GEOD-36284 | biostudies-arrayexpress
TranscriptomicsCoupled pre-mRNA and mRNA dynamics unveil the operation strategies underlying transcriptional responses
Transcriptional responses to stimuli are regulated by tuning rates of transcript production and degradation. Here we show that stimulation-induced changes in transcript production and degradation rates can be inferred from simultaneously measured precursor mRNA (pre-mRNA) and mature mRNA profiles. O...
ORGANISM(S): Homo sapiens 
2011-08-30 | E-GEOD-24391 | biostudies-arrayexpress
TranscriptomicsNaturally transmitted segmented filamentous bacteria segregate with diabetes protection in NOD mice
Vertebrates typically harbor a rich gastrointestinal microbiota, which has co-evolved with the host over millennia and is essential for several of its physiological functions, in particular maturation of the immune system. Recent studies have highlighted the importance of a single bacterial species,...
ORGANISM(S): Mus musculus 
2011-06-09 | E-GEOD-29806 | biostudies-arrayexpress
UnknownExpression of ALS-PFN1 impairs vesicular degradation in iPSC-derived microglia.
Not available
S-EPMC10954694 | biostudies-literature
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