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TranscriptomicsIntegrative analysis of haplotype-resolved epigenomes across human tissues
Allelic differences between the two sets of chromosomes can affect the propensity of inheritance in humans, but the extent of such differences in the human genome has yet to be fully explored. Here, we delineate allelic chromatin modifications and transcriptomes amongst a broad set of human tissues...
ORGANISM(S): Homo sapiens 
2015-02-18 | E-GEOD-58752 | biostudies-arrayexpress
TranscriptomicsStructural mapping of regulatory function of histone H3 and H4 residues
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Saccharomyces cerevisiae 
2012-12-05 | E-GEOD-29064 | biostudies-arrayexpress
GenomicsGlobal Reorganization of Chromatin Architecture during Embronic Stem Cell Differentiation
The 3D organization of the genome is important for regulation of diverse nuclear processes ranging from transcription to DNA replication. Knowledge of the higher order chromatin structure is critical for understanding mechanisms of gene regulation by long-range control elements such as enhancers and...
ORGANISM(S): Homo sapiens 
2015-02-18 | E-GEOD-52457 | biostudies-arrayexpress
GenomicsMnase-seq for six histone mutants and two wild-types in S. cerevisiae
Nucleosome structure directly influences gene transcription. However, the function of each histone residue remains largely unknown. Here we profiled gene expression changes upon the mutation of individual residues of histone H3 and H4. Histone residues grouped by expression change similarity dis...
ORGANISM(S): Saccharomyces cerevisiae 
2012-12-05 | E-GEOD-29026 | biostudies-arrayexpress
GenomicsGenome-wide maps of chromatin state in NCCIT cells
H2B mono-ubiquitylation is required for multiple methylations of both H3K4 and H3K79 and has been implicated in gene expression from yeast to human. However, molecular crosstalk between H2BUb1 and other modifications, especially H3K4 and H3K79 methylations, remains unclear in vertebrates. To underst...
ORGANISM(S): Homo sapiens 
2012-03-07 | E-GEOD-25882 | biostudies-arrayexpress
GenomicshDot1L and RNAPII-5p in NCCIT cells.
We generated high-throughput sequencing (ChIP-seq) data for genome wide occupancy of hDot1L and RNAPII-5p in human embryonic carcinoma cell. Performing ChIP-seq for hDot1L and RNAPII-5p in NCCIT cell lines (embryonic carcinoma cell lines in human).
ORGANISM(S): Homo sapiens 
2012-09-27 | E-GEOD-26598 | biostudies-arrayexpress
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