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ProteomicsTissue extracellular matrix hydrogels as alternative to Matrigel for culturing gastrointestinal organoids
Matrigel, a mouse tumor extracellular matrix (ECM) protein mixture, is an indispensable component of most organoid tissue culture. However, it has limited the utility of organoids for drug development and regenerative medicine due to its tumor-derived origin, batch-to batch variation, high cost, and...
ORGANISM(S): Sus scrofa (Pig) Mus musculus (Mouse) 
2022-02-10 | PXD023694 | Pride
Organoid Matrigel Lc-ms/ms 
ProteomicsTranscriptome and proteome analysis of the human corneal endothelium and aqueous humor reveal endothelial cell dysfunction markers
Background: The underlying mechanism as well as diagnostic molecular biomarkers for corneal endothelial cell dysfunction (CECD) remain elusive. This study aimed to elucidate molecular mechanism of CECD via proteomic and transcriptomic approaches and identify novel biomarkers in aqueous humor (AH) di...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD023772 | Pride
Proteomics Aqueous humor Corneal endothelial cell dysfunction Transcriptomics Biomarker Bullous keratopathy 
ProteomicsHuman synovial fluid proteomics reveals potential early-diagnostic biomarkers for ankylosing spondylitis
[Background] Ankylosing spondylitis (AS), affecting 0.5% of the population, is a chronic inflammatory rheumatic disease affecting the axial skeleton and peripheral joints. The etiology of this disease is still poorly understood, but it may be involved with the interaction of genetic and environmen...
ORGANISM(S): Homo sapiens (Human) 
2021-07-15 | PXD016620 | Pride
Synovial fluid Proteomics Biomarker Ankylosing spondylitis 
ProteomicsIntegrated Analysis of Global Proteome and Phosphoproteome in Cisplatin Resistant Bladder Cancer Cell Revealed the Molecular Signature Predictive to Patient Survival
Cisplatin-based chemotherapy is the standard care regimen in bladder cancer (BC). However, resistance to the therapy whose molecular mechanisms of the resistance are not fully elucidated rapidly develops in BC patients. Here we introduced multidimensional proteomic analysis providing different level...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD005308 | Pride
Phosphoproteomics Bladder cancer Cisplatin resistance Biological network Molecular signature 
ProteomicsPGRC Cancer Proteome Study of Gastric Tissue
The goal of the project is to analyze different layers of proteome information including protein abundance and post-translational modifications of PGRC gastric tissue samples. Three pairs of human gastric cancer and adjacent normal tissues were extensively characterized by serial enrichments of phos...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080818 | MassIVE
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