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TranscriptomicsChip-chip and MIRA-chip from primary skin fibroblasts, derived of matched pairs of early and late donor age
Aging signatures developed from a longitudinal study design are dominated by reduced transcription of genes involved in protein synthesis. Aging is a multifactorial process where the impact of singular components still remains unclear. Furthermore, previous studies were focused on measuring specific...
ORGANISM(S): Homo sapiens 
2014-10-23 | E-GEOD-51517 | biostudies-arrayexpress
GenomicsThe characteristics of genome-wide DNA methylation in naM-CM-/ve CD4+ T cells of patients with psoriasis and atopic dermatitis
Psoriasis and atopic dermatitis (AD) are characterized by polarized CD4+ T cell responses. During the polarization of naM-CM-/ve CD4+ T cells, DNA methylation plays an important role in the regulation of gene transcription. In this study, we profiled the genome-wide DNA methylation status of naM-CM-...
ORGANISM(S): Homo sapiens 
2012-03-17 | E-GEOD-35582 | biostudies-arrayexpress
TranscriptomicsReference Genes for MiRNAome Analysis of Urothelial Carcinomas
Background/Objective: Quantitative real-time PCR (RT-qPCR) is widely used in miRNA expression studies on cancer. To compensate for the analytical variability produced by the multiple steps of the method, relative quantification of the measured miRNAs is required, which is based on normalization to e...
ORGANISM(S): Homo sapiens 
2013-02-26 | E-GEOD-36121 | biostudies-arrayexpress
TranscriptomicsDifferential expression of microRNAs between oral squamous cell carcinoma and healthy control tongues
In order to identify aberrantly expressed microRNAs in oral squamous cell carcinomas (OSCCs), we have employed microRNA microarray profile using healthy tongue samples as control. All seventeen human OSCCs and three normal tongue tissues were collected from the Tissue Bank at the Moffitt Cancer Cent...
ORGANISM(S): Homo sapiens 
2012-09-05 | E-GEOD-28100 | biostudies-arrayexpress
TranscriptomicsComparison of gene expression profiles of miR-142-/- primary megakaryocytes and WT primary megakaryocytes
Whole fetal livers were collected from mouse fetuses at embryonic day 14.5 (E14.5), and single-cell suspensions were prepared by successive passage through 18-, 21 and 23-gauge needles. Fetal liver cells were maintained in Dulbecco modified Eagle medium (DMEM; Invitrogen) supplemented with 10% feta...
ORGANISM(S): Mus musculus 
2014-06-11 | E-GEOD-52141 | biostudies-arrayexpress
TranscriptomicsSmall RNA deep-sequencing identifies microRNAs and other small non-coding RNAs from human herpesvirus 6 (HHV-6B)
Roseolovirus, or human herpesvirus 6 (HHV-6) is a ubiquitous human pathogen infecting over 95% of the population by the age of two years. As with other herpesviruses, reactivation of HHV-6 can present with severe complications in immunocompromised individuals. Recent studies have highlighted the imp...
ORGANISM(S): Human herpesvirus 6B 
2012-01-01 | E-GEOD-34196 | biostudies-arrayexpress
GenomicsThe oncogenic microRNA hsa-mir-155-5p targets the transcription factor ELK3 and links it to the hypoxia response and the Hypoxia Inducible Factor HIF1M-NM-1
The molecular response to hypoxia is a critical cellular process implicated in cancer, and a target for drug development. The activity of the major player, HIF1M-NM-1,M-BM- is regulated at different levels, including the transcriptional level by the Ets factor ELK3. The molecular mechanisms of this ...
ORGANISM(S): Homo sapiens 
2014-12-04 | E-GEOD-60156 | biostudies-arrayexpress
TranscriptomicsDifferential expression of mRNAs in naM-CM-/ve, effector, and memory CD8 T cells of mir-150 KO and wild-type mice
microRNA-150 (miR-150) is mainly expressed in the lymph nodes and spleen and is highly up-regulated during the development of mature T and B cells. To understand the signal-transduction network for 'effector or memory T cells' and 'mir-150' in naM-CM-/ve, effector, or memory CD8 T cells of mir-150 k...
ORGANISM(S): Mus musculus 
2014-10-11 | E-GEOD-62262 | biostudies-arrayexpress
TranscriptomicsIdentification of metastamirs as metastasis-associated microRNAs in clear cell renal cell carcinomas
Background/Objective: MicroRNAs (miRNAs) play a pivotal role in cancerogenesis and cancer progression, but their specific role in metastasis of clear cell renal cell carcinomas (ccRCCs) as so-called metastamirs is still limited. Based on microRNA microarray analyses from normal (n=12) and cancerous ...
ORGANISM(S): Homo sapiens 
2013-02-26 | E-GEOD-37989 | biostudies-arrayexpress
TranscriptomicsmiRNA expression profiles in the 19 candidate urines (prostate cancer, CaP, patients and non-cancer subjects with benign prostatic hyperplasia, BPH)
The aims of the study were investigated whether expression of urinary cell-free miRNAs would be different between prostate cancer (CaP) patients and non-cancer subjects with benign prostatic hyperplasia (BPH). Urinary cell-free miRNAs will provide potential benefits for detecting CaP, and virus-enco...
ORGANISM(S): Homo sapiens 
2014-01-14 | E-GEOD-54010 | biostudies-arrayexpress
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