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ProteomicsThe E3 ubiquitin ligase HectD3 is a novel regulator of cardiac hypertrophy and inflammation
The HECT domain E3 ubiquitin protein ligase 3 (HectD3) is highly expressed in the heart, but its cardiac function is still unknown. Here, we identified SUMO2 and Stat1 as novel cardiac substrates for HectD3. SUMO2 is a potent inducer of Calcineurin-NFAT mediated cardiomyocyte hypertrophy, whereas, S...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-09-09 | PXD020843 | Pride
Ubiquitin ligase Cardiac models Proteomics 
TranscriptomicsCaM Kinase II mediates maladaptive post-infarct remodeling but not acute myocardial ischemia/reperfusion injury
Calcium/calmodulin-dependent protein kinase II (CaMKII) was suggested to mediate ischemic myocardial injury and adverse cardiac remodeling. However, the specific functions of the CaMKII isoforms and splice variants in ischemia/reperfusion (I/R) injury have not been investigated yet. Thus, we studied...
ORGANISM(S): Mus musculus 
2014-09-08 | E-GEOD-58486 | biostudies-arrayexpress
UnknownTIP30 counteracts cardiac hypertrophy and failure by inhibiting translational elongation
Not available
S-SCDT-EMM-2018-10018 | biostudies-other
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