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MetabolomicsAnalysis of the human adult urinary metabolome variations with age, body mass index and gender by implementing a comprehensive workflow for univariate and OPLS statistical analyses. ('Sacurine' data set)

Urine metabolomics is widely used for biomarker research in the fields of medicine and toxicology. As a consequence, characterization of the variations of the urine metabolome under basal conditions becomes critical in order to avoid confounding effects in cohort studies. Such physiological infor...

2017-01-20 | MTBLS404 | MetaboLights
MetabolomicsAnnotation of the human adult urinary metabolome and metabolite identification using ultra high performance liquid chromatography coupled to a LTQ-Orbitrap mass spectrometer
This study deals with the annotation of the human adult urinary metabolome and metabolite identification from electrospray-mass spectrometry (ESI-MS) based metabolomics datasets. Metabolite identification was achieved using two complementary approaches: (i) formal identification by matching chromato...
2013-07-26 | MTBLS20 | MetaboLights
MetabolomicsImpact of collection conditions on the metabolite content of human urine samples as analyzed by liquid chromatography coupled to mass spectrometry and nuclear magnetic resonance spectroscopy (LC-MS assay)
There is a lack of comprehensive studies documenting the impact of sample collection conditions on metabolic composition of human urine. To address this issue, two experiments were performed at a three-month interval, in which midstream urine samples from healthy individuals were collected, pooled, ...
2014-12-18 | MTBLS148 | MetaboLights
MetabolomicsProMetIS, deep phenotyping of mouse models by combined proteomics and metabolomics analysis

Genes are pleiotropic and getting a better knowledge of their function requires a comprehensive characterization of their mutants. Here, we generated multi-level data combining phenomic, proteomic and metabolomic acquisitions from plasma and liver tissues of two C57BL/6 N mouse models lacking the...

2021-09-01 | MTBLS1903 | MetaboLights
MetabolomicsStrong effect of Penicillium roqueforti populations on volatile and metabolic compounds responsible for aromas, flavour and texture in blue cheeses
Studies of food microorganism domestication can provide important insight into adaptation mechanisms and lead to commercial applications. Penicillium roqueforti is a fungus with four genetically differentiated populations, two of which were independently domesticated for blue cheese-making, with the...
2021-10-06 | MTBLS1509 | MetaboLights
TranscriptomicsExploration of the sulfur metabolism in the yeast Kluyveromyces lactis
A comparison between high and low sulfur source supplies, i.e., sulfate, methionine or cystine, was carried out in order to identify key steps in the biosynthetic and catabolic pathways of the sulfur amino acids. the transcriptomic study was carried out using Agilent 8X15k slides with a custom oligo...
ORGANISM(S): Kluyveromyces lactis 
2011-09-30 | E-GEOD-26013 | biostudies-arrayexpress
TranscriptomicsAn extensive investigation of sulfur metabolism in the yeast Yarrowia lipolytica
A comparison between high and low sulfur source supplies, i.e., sulfate, methionine or cystine, was carried out in order to identify key steps in the biosynthetic and catabolic pathways of the sulfur amino acids. Two conditions experiment, high versus low sulfur conditions (sulfate, cystine or methi...
ORGANISM(S): Yarrowia lipolytica 
2012-12-01 | E-GEOD-39834 | biostudies-arrayexpress
TranscriptomicsIsocitrate dehydrogenase 1 mutations prime the all-trans-retinoic acid myeloid differentiation pathway in acute myeloid leukemia HL-60 cells
Human acute myeloid leukemia HL60 cells were transduced with IDH1-WT or IDH1-R132H, and corresponding sub-clones were generated by FACS. In a first series of experiments, cells expressing wt and mutant IDH1were treated with either 1µM all-trans retinoic acid (ATRA) or with vehicle (DMSO) for 24 hrs...
ORGANISM(S): Homo sapiens 
2017-03-01 | E-MTAB-4327 | biostudies-arrayexpress
ProteomicsM.musculus - Plasma, SC (Imbertetal,scidata2021)
abundance based on Spectral counting, Interaction consistency score: 4.5, Coverage: 2
ORGANISM(S): 10090 
2021-00-00 | 8657263 | PAXDB
ProteomicsM.musculus - Liver, SC (Imbertetal,scidata2021)
abundance based on Spectral counting, Interaction consistency score: 15.1, Coverage: 10
ORGANISM(S): 10090 
2021-00-00 | 3188803864 | PAXDB
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