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UnknownThe Social Component of Environmental Enrichment Is a Pro-neurogenic Stimulus in Adult c57BL6 Female Mice.
In rodents, the hippocampal dentate gyrus gives rise to newly generated dentate granule cells (DGCs) throughout life. This process, named adult hippocampal neurogenesis (AHN), converges in the functional integration of mature DGCs into the trisynaptic hippocampal circuit. Environmental enrichment (E...
S-EPMC6497743 | biostudies-literature
UnknownPeripherally triggered and GSK-3β-driven brain inflammation differentially skew adult hippocampal neurogenesis, behavioral pattern separation and microglial activation in response to ibuprofen.
Both familial and sporadic forms of Alzheimer disease (AD) present memory impairments. It has been proposed that these impairments are related to inflammation in relevant brain areas such as the hippocampus. Whether peripherally triggered and neuron-driven brain inflammation produce similar and equa...
S-EPMC4350524 | biostudies-literature
UnknownRetroviral induction of GSK-3β expression blocks the stimulatory action of physical exercise on the maturation of newborn neurons.
Adult hippocampal neurogenesis (AHN) is a key process for certain types of hippocampal-dependent learning. Alzheimer's disease (AD) is accompanied by memory deficits related to alterations in AHN. Given that the increased activity of GSK-3β has been related to alterations in the population of hippoc...
S-EPMC11108461 | biostudies-literature
UnknownNovel function of Tau in regulating the effects of external stimuli on adult hippocampal neurogenesis.
Tau is a microtubule-associated neuronal protein found mainly in axons. However, its presence in dendrites and dendritic spines is particularly relevant due to its involvement in synaptic plasticity and neurodegeneration. Here, we show that Tau plays a novel in vivo role in the morphological and syn...
S-EPMC4876034 | biostudies-literature
UnknownSoluble Tau has devastating effects on the structural plasticity of hippocampal granule neurons.
Tau is a neuronal microtubule-associated protein with countless physiological functions. Although the detrimental effects of insoluble aggregated Tau have been widely studied, recent evidence supports the notion that soluble Tau (composed mostly of monomers and dimers) is also toxic for neurons. Her...
S-EPMC5802513 | biostudies-literature
UnknownGlycogen synthase kinase-3β regulates fractalkine production by altering its trafficking from Golgi to plasma membrane: implications for Alzheimer's disease.
Glycogen synthase kinase-3β (GSK-3β) is a serine-threonine kinase implicated in multiple processes and signaling pathways. Its dysregulation is associated with different pathological conditions including Alzheimer's disease (AD). Here we demonstrate how changes in GSK-3β activity and/or levels regul...
S-EPMC5309299 | biostudies-literature
UnknownThe transcriptional co-activator Yap1 promotes adult hippocampal neural stem cell activation.
Most adult hippocampal neural stem cells (NSCs) remain quiescent, with only a minor portion undergoing active proliferation and neurogenesis. The molecular mechanisms that trigger the transition from quiescence to activation are still poorly understood. Here, we found the activity of the transcripti...
S-EPMC10233373 | biostudies-literature
UnknownExtensive transcriptional and chromatin changes underlie astrocyte maturation in vivo and in culture.
Astrocytes have essential functions in brain homeostasis that are established late in differentiation, but the mechanisms underlying the functional maturation of astrocytes are not well understood. Here we identify extensive transcriptional changes that occur during murine astrocyte maturation in vi...
S-EPMC8282848 | biostudies-literature
UnknownAdeno-associated viral vector serotype 9-based gene therapy for Niemann-Pick disease type A.
Niemann-Pick disease type A (NPD-A) is a lysosomal storage disorder characterized by neurodegeneration and early death. It is caused by loss-of-function mutations in the gene encoding for acid sphingomyelinase (ASM), which hydrolyzes sphingomyelin into ceramide. Here, we evaluated the safety of cere...
S-EPMC7285630 | biostudies-literature
UnknownExcitotoxic inactivation of constitutive oxidative stress detoxification pathway in neurons can be rescued by PKD1.
Excitotoxicity, a critical process in neurodegeneration, induces oxidative stress and neuronal death through mechanisms largely unknown. Since oxidative stress activates protein kinase D1 (PKD1) in tumor cells, we investigated the effect of excitotoxicity on neuronal PKD1 activity. Unexpectedly, we ...
S-EPMC5741635 | biostudies-literature
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