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TranscriptomicsJuvenile hormone regulation of Drosophila aging
Background. Juvenile hormone (JH) has been demonstrated to control adult lifespan in a number of non-model insects where surgical removal of the corpora allata eliminates the source of hormone. In contrast, little is known about how juvenile hormone affects adult Drosophila melanogaster. Previous w...
ORGANISM(S): Drosophila melanogaster 
2013-07-26 | E-GEOD-48145 | biostudies-arrayexpress
MetabolomicsDietary Bacillus coagulans supplementation improves liver health and modulates hepatic metabolic profiles in juvenile fourfinger threadfin (Eleutheronema tetradactylum)

Dietary supplementation with probiotics has emerged as a promising strategy to enhance the health and productivity of farmed fish. This study investigated the effects of dietary Bacillus coagulans on the hepatic morphology, oxidative status, and metabolic profiles of juvenile fourfinger threadfin...

2026-07-23 | MTBLS15102 | MetaboLights
TranscriptomicsCharacterization of Directly Regulated Thyroid Hormone Mediated Gene Expression Following Short-Term Perturbations in Thyroid Hormone Levels in Juvenile Mice
We investigated the effects of thyroid hormone disruptions on gene expression in juvenile mice liver to develop a stronger understanding of the mechanisms by which thyroid disrupting chemicals impair development. Gene expression was examined by hybridization of hepatic RNA to Agilent mouse microarr...
ORGANISM(S): Mus musculus 
2012-03-29 | E-GEOD-21307 | biostudies-arrayexpress
MetabolomicsA multi-omics approach to study peroxisome proliferator-activated receptor mediated regulation of lipid metabolism in Atlantic cod (Gadus morhua)
Lipid metabolism is essential in maintaining energy homeostasis in multicellular organisms. In vertebrates, a group of nuclear receptor transcription factors named peroxisome proliferator-activated receptors (PPARs, NR1C) regulate the expression of many genes involved in these processes. We have rec...
2022-02-28 | MTBLS2131 | MetaboLights
TranscriptomicsTranscription profiling of Drosophila Hr39 mutant females reveals the sf1-related nuclear hormone receptor hr39 regulates Drosophila female reproductive tract development and function
The vertebrate nuclear hormone receptor steroidogenic factor 1 (SF1; NR5A1) controls reproductive development and regulates the transcription of steroid-modifying cytochrome P450 genes. We find that the SF1-related Drosophila nuclear hormone receptor HR39 is also essential for sexual development. In...
ORGANISM(S): Drosophila melanogaster 
2008-06-11 | E-GEOD-10264 | biostudies-arrayexpress
TranscriptomicsThe orphan nuclear hormone receptor ERR-beta controls rod photoreceptor survival.
Mutation of rod photoreceptor-enriched transcription factors is a major cause of inherited blindness. We identified the orphan nuclear hormone receptor ERRβ as selectively expressed in rod photoreceptors. Overexpression of ERRβ induces expression of rod-specific genes in retinas of both wildtype ...
ORGANISM(S): Mus musculus 
2010-07-30 | E-GEOD-21944 | biostudies-arrayexpress
ProteomicsJuvenile hormone membrane signaling phosphorylates USP to potentiate 20-hydroxyecdysone action and Yorkie activity in Drosophila
Juvenile hormone (JH) antagonizes 20-hydroxyecdysone (20E) signaling mainly through the intracellular receptors Met and Gce in Drosophila. To investigate JH membrane signaling pathway without the interference from JH intracellular signaling, we characterized phosphoproteome profiles of the Met gce d...
ORGANISM(S): Drosophila Melanogaster 
PXD021644 |
TranscriptomicsTranscription profiling of Drosophila female whole bodies treated with juvenile hormone
Juvenile hormone (JH) and 20-hydroxy-ecdysone (20E) are highly versatile hormones, coordinating development, growth, and reproduction in insects. Pulses of 20E provide key signals for initiating developmental and physiological transitions, while JH promotes or inhibits these signals in a stage-speci...
ORGANISM(S): Drosophila melanogaster 
2008-06-16 | E-GEOD-9001 | biostudies-arrayexpress
ProteomicsMass spectrometry identification of immunoprecipitated head samples of Colaphellus bowringi
We used immunoprecipitation to purify total proteins from the beetle using anti-JHAMT1. Subsequently, protein identification was carried out after excising the target area from the gel. This study aims to identify proteins that interact with JHAMT1 in the beetle
ORGANISM(S): Colaphellus Bowringi 
2025-01-24 | PXD060186 |
TranscriptomicsTranscriptomic analysis reveals the involvement of canonical Wnt signaling in zebrafish gonad differentiation
Zebrafish males undergo a juvenile ovary to testis type gonadal transformation process. To understand how juvenile ovary-to-testis transformation in zebrafish is genetically regulated, we compared the transcriptomes of juvenile ovary (JO) and juvenile ovotestis (JOT) samples at 35 dpf using the Gona...
ORGANISM(S): Danio rerio 
2013-12-27 | E-MEXP-3879 | biostudies-arrayexpress
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