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TranscriptomicsHistone H3 lysine 56 acetylation is linked to the core transcriptional network in human embryonic stem cells
Lysine 56 acetylation in the helical core of histone H3 opens yeast chromatin and enables histone gene transcription, DNA replication, DNA repair, and prevents epigenetic silencing. While K56Ac is globally abundant in yeast and flies its presence has been uncertain in mammals. We show here using mas...
ORGANISM(S): Homo sapiens 
2009-02-09 | E-GEOD-14749 | biostudies-arrayexpress
TranscriptomicsIsw1 and Chd1 maintain chromatin organization during transcription [K56ac data]
ChIP-chip assays to determine the occupancy of acetylated histone H3 K56 in wildtype, isw1, chd1, isw1 chd1 and ISW1[K227R] yeast. Two color experiment. ChIP/Input. K56ac data normalized to histone H3 and plotted as mutant over wildtype. Biological replicates=3. Please note that H3 data for YMS123-1...
ORGANISM(S): Saccharomyces cerevisiae 
2012-07-24 | E-GEOD-36405 | biostudies-arrayexpress
GenomicsA histone acetylation switch regulates H2A.Z deposition by the SWR-C remodeling enzyme
The histone variant H2A.Z plays key roles in gene expression, DNA repair, and centromere function. H2A.Z deposition is controlled by SWR-C chromatin remodeling enzymes that catalyze the nucleosomal exchange of canonical H2A with H2A.Z. Here we report that acetylation of histone H3 lysine 56 (H3-K56A...
ORGANISM(S): Saccharomyces cerevisiae W303 
2013-04-15 | E-GEOD-43935 | biostudies-arrayexpress
GenomicsSaccharomyces cerevisiae
Isw1 and Chd1 maintain chromatin organization during transcription [K56ac data]
PRJNA158631 | ENA
TranscriptomicsCell cycle- and chaperone-mediated regulation of H3K56ac incorporation in yeast
Acetylation of histone H3 lysine 56 is a covalent modification best-known as a mark of newly-replicated chromatin, but has also been linked to replication-independent histone replacement. Here, we measured H3K56ac levels at single-nucleosome resolution in asynchronously growing yeast cultures, as w...
ORGANISM(S): Saccharomyces cerevisiae 
2008-10-03 | E-GEOD-12822 | biostudies-arrayexpress
TranscriptomicsChromatin remodelers Isw1 and Chd1 maintain chromatin structure during transcription by preventing histone exchange
This SuperSeries is composed of the following subset Series: GSE32042: Isw1 and Chd1 maintain chromatin organization during transcription GSE32043: Histone exchange in wildtype, isw1, chd1, isw1 chd1 and ioc4 yeast strains GSE32044: Histone H3 K36me3 in wildtype, isw1 and chd1 yeast strains GSE32045...
ORGANISM(S): Saccharomyces cerevisiae 
2012-07-24 | E-GEOD-32071 | biostudies-arrayexpress
GenomicsAcetylated histone H3K56 interacts with Oct4 to promote mouse embryonic stem cell pluripotency
The presence of acetylated histone H3K56 in human embryonic stem cells (ESCs) correlates positively with the binding of Nanog, Sox2 and Oct4 (NSO) transcription factors at their target gene promoters. However, the function of H3K56ac there has been unclear. We now report that Oct4 interacts with K56...
ORGANISM(S): Mus musculus 
2013-06-25 | E-GEOD-47387 | biostudies-arrayexpress
GenomicsChromatin dynamics and the RNA exosome function in concert to regulate transcriptional homeostasis (ChIP-seq)
The histone variant H2A.Z is a hallmark of nucleosomes flanking the promoters of protein coding genes, and is often found in nucleosomes that also carry lysine 56- acetylated histone H3 (H3-K56Ac), a mark which promotes rapid replication- independent turnover of nucleosomes. Although H2A.Z and H3-K5...
ORGANISM(S): Saccharomyces cerevisiae 
2015-11-12 | E-GEOD-72692 | biostudies-arrayexpress
GenomicsA histone acetylation switch regulates H2A.Z deposition by the SWR-C remodeling enzyme
The histone variant H2A.Z plays key roles in gene expression, DNA repair, and centromere function. H2A.Z deposition is controlled by SWR-C chromatin remodeling enzymes that catalyze the nucleosomal exchange of canonical H2A with H2A.Z. Here we report that acetylation of histone H3 lysine 56 (H3-K56A...
ORGANISM(S): Saccharomyces cerevisiae W303 
2013-04-15 | GSE43935 | GEO
GenomicsFACT activity and histone H3-K56 acetylation promote optimal establishment of chromatin architecture independent of ongoing transcription in Saccharomyces cerevisiae [MNase-Seq]
FACT is a histone chaperone that can destabilize or assemble nucleosomes. Acetylation of histone H3-K56 weakens a histone:DNA contact that is central to FACT activity, suggesting that this modification could affect FACT functions. We tested this by asking how mutations of H3-K56 and FACT affect nucl...
ORGANISM(S): Saccharomyces cerevisiae 
2019-03-06 | GSE118330 | GEO
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