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TranscriptomicsTranscription profiling of human pancreatic duct epithelial cell line (H6c7) Gene expression changes induced by K-ras oncogene in the
k-ras oncogene was transduced into the HPV16-E6E7 immortalized normal human pancreatic duct epithelial cell line (H6c7) to generate a stable K-ras oncogene-expressing cell line (H6c7-Kr). The gene expression profile of the H6c7-Kr cells was compared to that of H6c7 cells. We have excluded (subtracte...
ORGANISM(S): Homo sapiens 
2008-06-11 | E-GEOD-1955 | biostudies-arrayexpress
TranscriptomicsA gene expression signature associated with K-Ras addiction reveals regulators of EMT and tumor cell survival
K-Ras mutations occur frequently in epithelial cancers. Using shRNAs to deplete K-Ras in lung and pancreatic cancer cell lines harboring K-Ras mutations, two classes were identified—lines that do or do not require K-Ras to maintain viability. Comparing these two classes of cancer cells revealed a g...
ORGANISM(S): Homo sapiens 
2009-03-06 | E-GEOD-15126 | biostudies-arrayexpress
TranscriptomicsTranscription profile of K-ras activated murine menstruating uteri
The expression of K-ras transgene is induced in K-rasV12+/-/Cre+/+/ROSA26R-LacZ+/+ transgenic mice uteri, which were primed with hormone treatment. Decidualization was artificially induced in these uteri and hormone injection was withdrawn to induced menstruation-like endometrial degeneration. Micr...
ORGANISM(S): Mus musculus 
2010-06-20 | E-GEOD-15518 | biostudies-arrayexpress
TranscriptomicsGene expression levels in colon cancer cells with mutant K-ras under hypoxic conditions
The goal of this study was to identify those genes that were differentially expressed in colon cancer cells with mutant K-ras under hypoxic conditions DKS-5 (K-ras mutant) and DKO-3 (K-ras wild-type) were cultured in normoxic (21% O2) and 12-hour hypoxic (1% O2) conditions. This was repeated for a ...
ORGANISM(S): Homo sapiens 
2012-02-21 | E-GEOD-35973 | biostudies-arrayexpress
GenomicsRNA expression profile (RNA-Seq) in mouse colonic tumors expressing endogenous K-Ras-WT, K-Ras-G12D, or K-RAS-G12D/K104Q
RNA expression profile (RNA-Seq) in mouse colonic tumors expressing endogenous K-Ras-WT, K-Ras-G12D, or K-RAS-G12D/K104Q
PRJNA978623 | ENA
TranscriptomicsNutrient-dependent growth of NIH3T3 and NIH3T3 K-ras cell lines.
Expression profiling of normal NIH3T3 and transformed NIH3T3 K-ras cell lines grown for 72 hours in optimal glucose availability (25 mM glucose) or low glucose availability (1 mM). Low glucose induces apoptosis in transformed cells as compared to normal ones. We performed genome-wide analysis by usi...
ORGANISM(S): Mus musculus 
2011-07-13 | E-GEOD-29962 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of tumor regression upon K-RAS inactivation
We performed expression profiling on micro-dissected lung tumors derived from a doxycycline-inducible K-RAS mouse model in order to gain mechanistic insight into K-RAS-mediated tumor maintenance. In this model, the tumors were induced with doxycycline for 11 weeks (in order to obtain lung tumors). A...
ORGANISM(S): Mus musculus 
2012-09-06 | E-GEOD-40606 | biostudies-arrayexpress
GenomicsEphexin1 cooperates with K-Ras to promote oncogenic Ras-driven tumorigenesis
Ephexin1 cooperates with K-Ras to promote oncogenic Ras-driven tumorigenesis
PRJNA619876 | ENA
GenomicsRNA expression profile (RNA-Seq) in mouse colonic epithelium expressing endogenouse K-Ras-WT or oncogenic K-Ras-G12D
RNA expression profile (RNA-Seq) in mouse colonic epithelium expressing endogenouse K-Ras-WT or oncogenic K-Ras-G12D
PRJNA784256 | ENA
TranscriptomicsMutant K-ras promotes carcinogen-induced murine colorectal tumourigenesis, but does not alter tumour chromosome stability
K-ras mutations are observed in around 40% human colorectal adenomas and carcinomas and contribute to the pathogenesis of human and rodent colorectal tumour formation. Previously, we developed and characterised a strain of transgenic mice with inducible intestinal epithelial expression of K-rasVal12...
ORGANISM(S): Mus musculus 
2010-10-02 | E-GEOD-24010 | biostudies-arrayexpress
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