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TranscriptomicsTranscription profiling of human K562 cells overexpressing miR-34a
miR-34a is strongly induced upon TPA-induced megakaryocyte differentiation of K562 cells. To investigate the gene networks regulated by this miRNA during the process of differentiation we performed gene microarray analysis in K562 cells overexpressing miR-34a or a control sequence. Experiment Overal...
ORGANISM(S): Homo sapiens 
2009-07-19 | E-GEOD-16674 | biostudies-arrayexpress
TranscriptomicsTranscriptomes of K562 cell line
To investigate the expression level of genes in K562 cells Profiling the transcriptome of K562
ORGANISM(S): Homo sapiens 
2013-07-15 | E-GEOD-39374 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human erythroleukemia K562 cells during TPA-induced megakaryocyte differentiation
Analysis of differential gene expression during TPA-induced megakaryocyte differentiation of human erythroleukemia K562 cells. The transcription profile of untreated vs TPA-treated K562 cells for 2 days was compared using gene microarrays.
ORGANISM(S): Homo sapiens 
2009-09-01 | E-MEXP-2213 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human tamoxifen treated myeloid leukemia K562-MERT cells
K562 cells, a myeloid leukemia cells line, were engineered to express a tamoxifen inducible dominant negative Myb (MERT). K562-MERT cells were cultured for 3 days in the absence and presence of 1 uM tamoxifen. The RNA was then extracted from the untreated and tamoxifen treated K562-MERT cells and ...
ORGANISM(S): Homo sapiens 
2004-06-30 | E-MEXP-91 | biostudies-arrayexpress
TranscriptomicsDynamics of intercellular and extracellular (exosomal) miRNAs in hypoxic K562 cells
Recently, the existence of extracellular miRNAs enclosed in exosomes has raised the possibility that they play an important role in cell-cell communication. To gain more insight into cell-cell communication via exosomal miRNAs, we investigated whether or not tumor cells exposed to hypoxia secrete ex...
ORGANISM(S): Homo sapiens 
2013-12-03 | E-GEOD-45289 | biostudies-arrayexpress
TranscriptomicsRegulation of hTERT by BCR-ABL at multiple levels in K562 cells
To investigate the mechanism of telomerase regulation in BCR-ABL positive cells due to its clinical value, we studied the catalytic component of telomerase, TERT. Our results suggest that BCR-ABL plays an important role in regulating hTERT in K562 (BCR-ABL positive human leukemia) cells. When Gleeve...
ORGANISM(S): Homo sapiens 
2011-12-15 | E-GEOD-26821 | biostudies-arrayexpress
GenomicsGlobal analysis of in vivo EGR1-binding sites in erythroleukemia cell K562 using chromatin immunoprecipitation and massively parallel sequencing
Early growth response gene 1 (EGR1) has been implicated in megakaryocyte differentiation induced by PMA (phorbol 12-myristate 13-acetate). The identification of direct EGR1 target genes in global scale is critical for our understanding of how EGR1 contributes to this process. In this study, we provi...
ORGANISM(S): Homo sapiens 
2010-09-08 | E-GEOD-21665 | biostudies-arrayexpress
TranscriptomicsChanges in the expression of miR-381 and miR-495 are inversely associated with the expression of the MDR1 gene and development of multi-drug resistance
Multidrug resistance (MDR) frequently develops in cancer patients exposed to chemotherapeutic agents and is usually brought about by over-expression of P-glycoprotein (P-gp) which acts as a drug efflux pump. MiRNAome profiling using next-generation sequencing identified differentially expressed micr...
ORGANISM(S): Homo sapiens 
2013-10-29 | E-GEOD-51774 | biostudies-arrayexpress
GenomicsGenome-wide mapping of RNA Pol III binding site (K562)
We report the results of chromatin immunoprecipitation following by high-thoughput tag sequencing (ChIP-Seq) using the GA II platform from Illumina for the human RNA Polymerase III in K562 cells. We have also generated a sequenced input DNA datasets for K562 cells. For data usage terms and conditi...
ORGANISM(S): Homo sapiens 
2009-12-31 | E-GEOD-19548 | biostudies-arrayexpress
TranscriptomicsTranscription profiling timecourse of human K562 cell line exposure to hemin
K562 cells (duplicate cultures A & B) are treated with 50 micromolar hemin for 0, 6, 12, 24, 48, 72 hours followed by RNA extraction and gene expression profiling on Affymetrix human U133A arrays and analysis by MAS 5.0
ORGANISM(S): Homo sapiens 
2007-07-19 | E-GEOD-1036 | biostudies-arrayexpress
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