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GenomicsComparative genome-wide DNA methylation analysis of colorectal tumor and matched normal tissues
In our study we applied a genome-wide DNA methylation analysis approach, MethylCap-seq, to map the differentially methylated regions in 24 tumor and matched normal colon samples. In total, 2687 frequently hypermethylated and 468 frequently hypomethylated regions were identified, which include potent...
ORGANISM(S): Homo sapiens 
2012-10-26 | E-GEOD-39068 | biostudies-arrayexpress
GenomicsThe DNA methylome of Epiblast Stem Cells and Embryonic Stem Cells is distinct and not fully reversible
Embryonic Stem Cells (ESCs) and Epiblast Stem Cells (EpiSCs) are the in vitro representants of naM-CM-/ve and primed pluripotency, respectively. It is currently unclear how their epigenome underpin the phenotypic and molecular characteristics of these states of pluripotency. Here, we performed the f...
ORGANISM(S): Mus musculus 
2014-04-28 | E-GEOD-47793 | biostudies-arrayexpress
TranscriptomicsTranscription profile of the Plasmodium falciparum intraerythrocytic cycle
This experiment characterizes the transcriptome of the human malaria parasite, P. falciparum at 8 different stages of the intraerythrocytic cycle Examination of polyA selected RNA in Plasmodium falciparum 3D7 strain at 8 different stages using RNA-seq
ORGANISM(S): Plasmodium falciparum 3D7 
2010-10-28 | E-GEOD-23865 | biostudies-arrayexpress
TranscriptomicsRepresentative Illumina sequencing libraries upon T7-polymerase based amplification
This experiment highlights the extreme sequence bias generated by standard PCR amplication of sequencing libraries and decribes an adapted T7-polymerase based amplification method, which results in non-baised, representative libraries for Illumina sequencing Adaptation of standard Illumina sequencin...
ORGANISM(S): Plasmodium falciparum 3D7 
2010-10-28 | E-GEOD-23868 | biostudies-arrayexpress
GenomicsEpigenetic profile of the Plasmodium falciparum intraerythrocytic cycle
This experiment characterizes the localisation of H2A.Z, H3K9ac and H3K4me3 in the epigenome of the human malaria parasite, P. falciparum at 4 different stages of intraerythrocytic development. Examination of H2A.Z, H3K9ac, H3K4me3 and mono-nucleosomal input in 3D7 strain at 4 different stages and H...
ORGANISM(S): Plasmodium falciparum 3D7 
2010-10-28 | E-GEOD-23867 | biostudies-arrayexpress
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