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TranscriptomicsGene expression profiling of lung cancer cells transfected with scrambled siRNA and siRNA targeting the ETS2 gene
ETS2 is a canonical transcriptional factor and member of the ETS family of genes. ETS2 binds to consensus ERE binding sites in a broad spectrum of genes thus affecting many intracellular molecular functions. However, the role of ETS2 in the biology and pathogenesis of lung cancers is still not known...
ORGANISM(S): Homo sapiens 
2013-11-01 | E-GEOD-43459 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of lung adenocarcinomas and normal lung tissue
Lung cancer is still the leading cause of cancer-related deaths in the US and worldwide. Understanding the global molecular profiles or transcriptome of lung cancers would strengthen our understanding of the biology of this malignancy. We performed gene expression profiling using the Human Gene 1.0 ...
ORGANISM(S): Homo sapiens 
2013-08-06 | E-GEOD-43458 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human lung vitro carcinogenesis system
Genes differentially expressed among cells constituting an in vitro human lung carcinogenesis model consisting of normal, immortalized, transformed and tumorigenic bronchial epithelial cells were identified. The differentially expressed genes were then analyzed to determine their relevance to the ge...
ORGANISM(S): Homo sapiens 
2009-07-24 | E-GEOD-17073 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of the adjacent airway field cancerization in early stage NSCLC
Previous work has shown that lung tumors and normal-appearing adjacent lung tissues share specific abnormalities that may be highly pertinent to the pathogenesis of lung cancer. However, the global and molecular adjacent airway field cancerization in non-small cell lung cancer (NSCLC) has not been c...
ORGANISM(S): Homo sapiens 
2014-03-04 | E-GEOD-44077 | biostudies-arrayexpress
TranscriptomicsGenomic landscape affected by allelic imbalance in the cancerization filed of normal appearing airway
Normal appearing airway samples from non-small cell lung (NSCLC) cancer patients were profiled using illumina sequencing arrays. Allelic imbalance was detected in normal-appearing large and small airway samples and affected known lung cancer driver genes. Multiple airway samples from 45 patients wer...
ORGANISM(S): Homo sapiens 
2016-08-10 | E-GEOD-80519 | biostudies-arrayexpress
TranscriptomicsDifferential gene expression patterns signifying loss of the mouse tumor supressor Gprc5a in lung epithelial cells
Increasing the understanding of the impact of changes in oncogenes and tumor suppressor genes is essential for improving the management of lung cancer. Recently, we identified a new mouse lung-specific tumor suppressor - the G-protein coupled receptor 5A (Gprc5a). We sought to understand the molecul...
ORGANISM(S): Mus musculus 
2010-04-13 | E-GEOD-21309 | biostudies-arrayexpress
TranscriptomicsCharacterizing the molecular spatial and temporal field of injury in early stage smoker non-small cell lung cancer patients after definitive surgery by expression profiling
Gene expression alterations in response to cigarette smoke have been characterized in normal-appearing bronchial epithelium of healthy smokers and it has been suggested that adjacent histologically normal tissue display tumor-associated molecular abnormalities. We sought to delineate the spatial and...
ORGANISM(S): Homo sapiens 
2012-12-01 | E-GEOD-40407 | biostudies-arrayexpress
TranscriptomicsUpregulated stromal EGFR and vascular remodeling in human NSCLC murine models (xenografts) of VEGF inhibitor resistance
The mechanisms by which tumors develop resistance to angiogenesis inhibitors, and the relative contributions of tumor cells and stroma to resistance, are not completely understood. We developed three human lung adenocarcinoma murine models of resistance to the VEGF inhibitor bevacizumab and, using s...
ORGANISM(S): Homo sapiens 
2011-04-22 | E-GEOD-26644 | biostudies-arrayexpress
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