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ProteomicsPan-cancer plasma proteome profiling using SIS recombinant protein fragments reveals downregulation of proteins interacting with immunoglobulins in multiple myeloma
Mass spectrometry based on Data Independent Acquisition (DIA) strategies has developed into powerful tools suitable for precision medicine applications. Assays performed in this setting provide confident protein identification and precise quantification on an absolute scale when combined with stable...
ORGANISM(S): Homo Sapiens 
PXD037946 | panorama
TranscriptomicsRevealing Targeted Therapy for Human Cancer by Gene Module Maps
A major goal of cancer research is to match specific therapies to molecular targets in cancer. Genome-scale expression profiling has identified new subtypes of cancer based on consistent patterns of variation in gene expression, leading to improved prognostic predictions. However, how these new gene...
ORGANISM(S): Homo sapiens 
2010-06-29 | E-GEOD-8957 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human myeloma cell lines
30 human myeloma cell lines
ORGANISM(S): Homo sapiens 
2010-12-23 | E-TABM-1088 | biostudies-arrayexpress
TranscriptomicsDeciphering myeloma risk loci by eQTL analysis
Recent genome-wide association studies have identified single nucleotide polymorphisms (SNPs) at 7 loci influencing multiple myeloma (MM) risk. We generated expression quantitative trait loci (eQTL) data on malignant plasma cells from two patient series (totaling 848) to fine map the risk loci assoc...
ORGANISM(S): Homo sapiens 
2014-12-09 | E-MTAB-2299 | biostudies-arrayexpress
TranscriptomicsComparing gene expression in stem/progenitor cells from patients with CML in chronic, accelerated and blastic phase with normal volunteers
A comparison of global gene expression between rigorously defined stem and progenitor cells from patients with chronic myeloid leukaemia (CML) in chronic (CP), accelerated (AP) and blastic (BC) phase and similar populations isolated from normal volunteers. Cryopreserved CD34+ enriched cell populatio...
ORGANISM(S): Homo sapiens 
2013-09-06 | E-GEOD-47927 | biostudies-arrayexpress
TranscriptomicsMyeloma in African Americans: Myeloma gDNA vs. Control gDNA
Epidemiological data have suggested that African Americans (AA) are twice as likely to be diagnosed with multiple myeloma (MM) as compared to European Americans (EA). Here, we have analyzed a set of cytogenetic and genomic data derived from AA and EA MM patients. We have compared the frequency of ...
ORGANISM(S): Homo sapiens 
2013-02-25 | E-GEOD-44271 | biostudies-arrayexpress
TranscriptomicsDNA methylation prevents CTCF-mediated silencing of the oncogene BCL6 in B cell lymphomas
Elevated DNA methylation in the first intronic region of the BCL6 locus in B cell lymphomas enforces transcription of the BCL6 gene Promoter tiling arrays were used to investigate the distribution of DNA methylation near the promoter region of BCL6 locus Comparison of DNA methylation at promoter reg...
ORGANISM(S): Homo sapiens 
2010-08-20 | E-GEOD-22884 | biostudies-arrayexpress
TranscriptomicsHypoxia-inducible factor (Hif)-1 knockdown blocks tumor growth, myeloma-induced angiogenesis and bone destruction in vivo
In multiple myeloma (MM), hypoxia-inducible transcription factor-1 (HIF-1) is overexpressed in the MM cells of the hypoxic bone marrow (BM) microenvironment. Herein, we explored in MM cells the in vitro and in vivo effects of persistent HIF-1 inhibition by expression of a lentivirus shRNA pool on pr...
ORGANISM(S): Homo sapiens 
2013-04-01 | E-GEOD-40326 | biostudies-arrayexpress
Genomics463 newly diagnosed patients with Multiple Myeloma underwent whole exome sequencing of tumour and peripheral blood DNA.
463 newly diagnosed patients from the UK Myeloma XI clinical trial (NCT01554852) underwent whole exome sequencing plus targeted capture of the IGH/K/L and MYC loci. 200 ng of DNA were processed using NEBNext DNA library prepartion kit and hybridised to the SureSelect Human All Exon V5 Plus. Four s...
EGAS00001001147 | EGA
TranscriptomicsIntegrated mutation, copy number and expression profiling in resectable non-small cell lung cancer
Study aims: to identify critical genes involved in non-small cell lung cancer (NSCLC) pathogenesis that may lead to a more complete understanding of this disease and identify novel molecular targets for use in the development of more effective therapies. Methods: Both transcriptional and genomic pro...
ORGANISM(S): Homo sapiens 
2010-11-27 | E-GEOD-25326 | biostudies-arrayexpress
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