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ProteomicsPeripheral priming induces plastic transcriptomic and proteomic responses in circulating neutrophils required for pathogen containment
Neutrophils rapidly respond to inflammation and infection, but to which degree their functional trajectories after mobilization from the bone marrow can be shaped within the circulation remains vague. Phenotypic changes of circulating neutrophils caused by systemic inflammation are thought to result...
ORGANISM(S): Homo sapiens (Human) 
2024-05-21 | PXD048335 | Pride
Neutrophils - transcriptomic plasticity - sepsis - infectious disease - multiomics 
MetabolomicsUltra-High Mass Resolving Power, Mass Accuracy, and Dynamic Range MALDI Mass Spectrometry Imaging by 21-T FT-ICR MS

Detailed characterization of complex biological surfaces by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) requires instrumentation that is capable of high mass resolving power, mass accuracy and dynamic range. Fourier transform ion cyclotron resonance mass sp...

2022-01-28 | MTBLS3154 | MetaboLights
UnknownGraft-versus-host disease and graft-versus-tumor effects after allogeneic hematopoietic cell transplantation.
Not available
S-EPMC3625710 | biostudies-literature
TranscriptomicsRNA-seq experiment to investigate the effect of inactivating the Apoptosis Antagonizing Transcription Factor (Aatf)
Human nephronophthisis and related ciliopathies suggest a link between ciliary signaling defects and altered DNA damage responses. The goal of our study is to elucidate the molecular link of both signaling systems as well as the role of altered DNA damage responses in kidney degeneration and fibrosi...
ORGANISM(S): Mus musculus 
2019-03-31 | E-MTAB-7077 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human macrophage Mono-Mac-6 cell or HUVEC cell one treated with leukotriene
Human umbilical vein endothelial cells (HUVEC) or the human macrophage cell line, Mono-Mac-6, treated with Leukotriene D4 for 1 hour
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-1644 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of Arabidopsis after infection with different strains of Agrobacterium tumefaciens
This study focuses on responses of the host plant to infection with Agrobacterium tumefaciens. Genome wide changes in gene expression were integrated with the alterations in metabolite levels three hours after inoculation of agrobacteria. Plants were infected with the virulent strain C58, harboring ...
ORGANISM(S): Arabidopsis thaliana 
2009-12-02 | E-GEOD-13929 | biostudies-arrayexpress
MetabolomicsEstimating essential phenotypic and molecular traits from integrative biodiversity data

Functional ecology and biodiversity lack integrative reference data that combine the assessment of traits at different levels. Here, we integrate data from 16 field samples of complex thallose liverworts (order Marchantiales) collected from biological soil crust communities in Southern Sweden and...

2024-06-05 | MTBLS2239 | MetaboLights
ProteomicsAnalysis of the effect of ClpC1 directed antibiotics on ClpC1, ClpC2 and ClpC3 protein levels.
Ecumicin and Cyclomarin A (CymA) are known antimicrobial compounds that target the NTD of ClpC1. In proteomics analysis of compound treated M. smegmatis, two novel protein, ClpC2 and ClpC3, have been identified as strong interactors of those compounds in addition to ClpC1. In this study we used PRM ...
ORGANISM(S): Mycolicibacterium Smegmatis 
PXD037198 | panorama
UnknownGenome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders.
Not available
S-EPMC6218410 | biostudies-literature
UnknownA prognostic model for use before elective surgery to estimate the risk of postoperative pulmonary complications (GSU-Pulmonary Score): a development and validation study in three international cohorts.
Not available
S-EPMC12056793 | biostudies-literature
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