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TranscriptomicsExpression analysis of genes located in the minimally deleted regions of 13q14 and 11q22-23 in chronic lymphocytic leukemia – unexpected expression pattern of the RHO GTPase activator ARHGAP20
In chronic lymphocytic leukemia (CLL), 13q14 and 11q22-23 deletions are found in 2/3 of the cases. 11q22-23 deletions are associated with poor survival, whereas 13q14 deletions as single abnormality are often found in indolent disease forms. The molecular basis for this difference in prognosis is no...
ORGANISM(S): Homo sapiens 
2011-10-13 | E-GEOD-25571 | biostudies-arrayexpress
TranscriptomicsAn eight-gene expression signature for the prediction of survival and time to treatment in chronic lymphocytic leukemia
Chronic lymphocytic leukemia (CLL) is a common and heterogeneous disease. An accurate prediction of outcome is highly relevant for the development of personalized treatment strategies. Microarray technology was shown to be a useful tool for the development of prognostic gene expression scores. Howev...
ORGANISM(S): Homo sapiens 
2011-10-13 | E-GEOD-22762 | biostudies-arrayexpress
ProteomicsGenome-Wide CRISPR-Cas9 Screening Identifies a Synergy between Hypomethylating Agents and SUMOylation Blockade in Myelodysplastic Syndromes and Acute Myeloid Leukemia
Hypomethylating agents (HMAs) are frontline therapies effective at altering the natural course of Myelodysplastic Neoplasms (MDS). However, acquired resistance and treatment failure are hallmarks of HMA therapy. Developing effective and rational HMA-focused combinatorial therapies is challenging as...
ORGANISM(S): Homo sapiens (Human) 
2024-07-25 | PXD050539 | Pride
Myelodysplastic neoplasms Proteomics Genome-wide crispr-cas9 screen Sumo 
UnknownTOPORS E3 ligase mediates resistance to hypomethylating agent cytotoxicity in acute myeloid leukemia cells.
Not available
S-EPMC11358519 | biostudies-literature
UnknownContribution of mutant HSC clones to immature and mature cells in MDS and CMML, and variations with AZA therapy.
Not available
S-EPMC10651766 | biostudies-literature
UnknownEvofosfamide for the treatment of human papillomavirus-negative head and neck squamous cell carcinoma.
Not available
S-EPMC6141174 | biostudies-literature
UnknownClinical response to azacitidine in MDS is associated with distinct DNA methylation changes in HSPCs.
Not available
S-EPMC12075701 | biostudies-literature
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