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TranscriptomicsGene-expression changes resulting from loss of the mTORC1 component Raptor in murine hematopoietic stem and progenitor cell-enriched populations (HSPC)
We investigated the role of mTORC1 in murine hematopoiesis by conditionally deleting the Raptor gene in murine hematopoietic stem cells. We observed mutliple alterations evoked by Raptor loss in hematopoiesis and profiled gene-expression alterations induced by raptor loss in Flt3-Lin-Sca1+cKit+ hema...
ORGANISM(S): Mus musculus 
2012-09-19 | E-GEOD-32265 | biostudies-arrayexpress
UnknownFlow-cytometric phosphoprotein analysis reveals agonist and temporal differences in responses of murine hematopoietic stem/progenitor cells.
Not available
S-EPMC2582484 | biostudies-literature
TranscriptomicsDepletion of Jak2V617F MPN-propagating stem cells by interferon-alpha in a murine model of polycythemia vera
Interferon alpha (IFNa) is an effective treatment for patients with myeloproliferative neoplasms (MPN). In addition to inducing hematological responses in most MPN patients, IFNa reduces the JAK2V617F allelic burden and can render the JAK2V617F mutant clone undetectable in some patients. The precise...
ORGANISM(S): Mus musculus 
2013-03-09 | E-GEOD-44961 | biostudies-arrayexpress
UnknownKRas(G12D)-evoked leukemogenesis does not require β-catenin.
Not available
S-EPMC4367949 | biostudies-literature
UnknownLeukemogenic Ptpn11 causes fatal myeloproliferative disorder via cell-autonomous effects on multiple stages of hematopoiesis.
Not available
S-EPMC2676094 | biostudies-literature
UnknownArterial damage and cognitive decline in chronic kidney disease patients.
Not available
S-EPMC8031195 | biostudies-literature
UnknownTransmembrane Inhibitor of RICTOR/mTORC2 in Hematopoietic Progenitors.
Not available
S-EPMC4235746 | biostudies-literature
UnknownAmino acid-insensitive mTORC1 regulation enables nutritional stress resilience in hematopoietic stem cells.
Not available
S-EPMC5373863 | biostudies-literature
UnknownSocioeconomic disparity is associated with faster retinal neurodegeneration in multiple sclerosis.
Not available
S-EPMC8759504 | biostudies-literature
UnknownmTOR complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis.
Not available
S-EPMC3743253 | biostudies-literature
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