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TranscriptomicsPerinatal malnutrition in male mice influences gene expression in the next generation offspring: Potential role of epigenetics.
Perinatal nutritional imbalances may have long-lasting consequences on health and disease, increasing risk of obesity, insulin resistance, type 2 diabetes or cardiovascular disease. This idea has been conceptualized in the Developmental Origins of Health and Disease Hypothesis (DOHaD). In additi...
ORGANISM(S): Mus musculus 
2015-02-01 | E-GEOD-55304 | biostudies-arrayexpress
TranscriptomicsDifferential RNAs in the sperm cells of asthenozoospermic patients
Alterations in the presence of sperm RNAs have been identified using microarrays in teratozoospermic (abnormal morphology) or other types of infertile patients. However, so far no studies had been reported on the sperm RNA content using microarrays in asthenozoospermic patients (low motility). We st...
ORGANISM(S): Homo sapiens 
2012-03-15 | E-GEOD-34514 | biostudies-arrayexpress
TranscriptomicsExpression data from docetaxel-resistant prostate cancer cell lines
Docetaxel-based chemotherapy is the standard first-line therapy in metastatic castration-resistant prostate cancer. However, most patients eventually develop resistance to this treatment. The aim of the study was to identify key molecular genes and networks associated with docetaxel resistance in 2 ...
ORGANISM(S): Homo sapiens 
2012-01-01 | E-GEOD-33455 | biostudies-arrayexpress
TranscriptomicsVastus lateralis biopsies from healthy and COPD patients before and after 8 weeks of exercise training
Study the training exercise effects in chronic obstructive pulmonary disease (COPD) patients and aged-matched healthy individuals. Skeletal muscle biopsies from 9 stable COPD patients with normal fat free mass index (FFMI, 21Kg/m2) (COPDN), 6 COPD patients with low FFMI (16Kg/m2) (COPL), and 12 hea...
ORGANISM(S): Homo sapiens 
2013-11-16 | E-GEOD-27536 | biostudies-arrayexpress
TranscriptomicsTime series of Balb/c spleen infected with Plasmodium yoelii non-lethal vs lethal strains
Knowledge on the dynamic features of the processes driven by malaria parasites in the spleen, our biggest lymphoid organ, is lacking. We have implemented intravital microscopy and magnetic resonance imaging of the mouse spleen in experimental infections with the Plasmodium yoelii non-lethal (17X) an...
ORGANISM(S): Mus musculus 
2010-10-12 | E-GEOD-17603 | biostudies-arrayexpress
TranscriptomicsGene expression profile after dexamethasone in chronic lymphocytic leukemia cells according to IGHV/ZAP-70 status
Glucocorticoids are part of the therapeutic armamentarium of chronic lymphocytic leukemia where it has been suggested that cells with unmutated IGHV genes exhibit higher sensitivity. The mechanisms by which glucorticoids are active in CLL are not well elucidated. We used microarrays to detail the gl...
ORGANISM(S): Homo sapiens 
2012-12-04 | E-GEOD-33135 | biostudies-arrayexpress
TranscriptomicsMuscle from patients with mitochondrial myopathies and congenital muscular dystrophies versus normal human muscle
Global gene expression analysis was performed comparing human skeletal muscle samples from patients with various forms of muscular dystrophy and mitochondrial myopathies in order to identify specific gene expression changes associated with collagen VI deficiency (leading to UllrichM-BM-4s Congenita...
ORGANISM(S): Homo sapiens 
2015-01-20 | E-GEOD-43698 | biostudies-arrayexpress
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