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TranscriptomicsEpigenetic regulation of the MEG3-DLK1 microRNA cluster in human Type 2 diabetic islets
Type 2 diabetes mellitus (T2DM) is a complex disease characterized by the inability of the insulin-producing β-cells in the endocrine pancreas to overcome insulin resistance in peripheral tissues. To determine if microRNAs are involved in the pathogenesis of human T2DM, we sequenced the small RNAs o...
ORGANISM(S): Homo sapiens 
2013-11-22 | E-GEOD-51924 | biostudies-arrayexpress
TranscriptomicsDynamic Recruitment of miRNAs to their mRNA Targets in Regenerating Liver
Validation of physiologic miRNA targets has been met with significant challenges. We employed HITS-CLIP to identify which miRNAs participate in liver regeneration, and to identify their target mRNAs. miRNA recruitment to the RISC is highly dynamic, changing more than five-fold for several miRNAs. m...
ORGANISM(S): mouse 
2013-04-25 | E-MTAB-1612 | biostudies-arrayexpress
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