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ProteomicsMultiOMICs landscape of SARS-CoV2-induced host responses in human lung epithelial cells
COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection continues to be a global health pandemic. Despite the availability of vaccines and approved therapeutics, the emergence of newer plausible resistant variants continues to be on the rise. Several multi-omics stu...
ORGANISM(S): Homo sapiens (Human) 
2023-01-18 | PXD032677 | Pride
Sars-cov-2 Inflammation Multi-omics Innate immune signaling Functional networks Covid-19 Signaling 
ProteomicsDose-dependent phorbol 12-myristate-13-acetate mediated monocyte-to-macrophage differentiation induces unique proteomic signatures in THP1 cells
Macrophages are sentinels of the immune system and THP1 monocytic cells are one of the widely used models to study immune responses in macrophages. Several monocyte-to-macrophage differentiation protocols exist with phorbol 12-myristate-13-acetate (PMA) being widely used and accepted. However, the c...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD015872 | Pride
Functional networks Cytokines and chemokines Macrophage differentiation Innate immune signaling 
ProteomicsA proteomic map of SUP-T1 cells
CD4+ T cells (T helper cells) are cytokine-producing adaptive immune cells that activate or regulate the responses of different immune cells. They are known to play crucial roles in antibody class switching in B cells, neutrophil recruitment and activation of macrophages and CD8+ cytotoxic T cells. ...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD021272 | Pride
Mass spectrometry Cd4+ t helper cells T lymphocytes Label-free quantitation Systems biology Adaptive immunity 
ProteomicsA proteomic map of resting and activated CD4+ T cells
CD4+ T cells (T helper cells) are cytokine-producing adaptive immune cells that activate or regulate the responses of different immune cells. They are known to play crucial roles in antibody class switching in B cells, neutrophil recruitment and activation of macrophages and CD8+ cytotoxic T cells. ...
ORGANISM(S): Homo sapiens (Human) 
2023-01-18 | PXD021250 | Pride
Mass spectrometry Cd4+ t helper cells T lymphocytes Label-free quantitation Systems biology Adaptive immunity 
TranscriptomicsRNA-Seq of wild-type HEK293 and K562 celllines
RNA-Seq was carried out in order to obtain the expression profile of Solute Carrier Family (SLC) of proteins in two commonly used celllines. We were specifically interested in the subset of SLCs that are capable of transporting amino acids.
ORGANISM(S): Homo sapiens 
2015-01-07 | E-MTAB-3102 | biostudies-arrayexpress
ProteomicsMissing proteins identified from the haploid cell lines: HAP1 and KBM-7
Chromosome-centric Human Proteomic Project (C-HPP) aims at identifying and characterizing protein products encoded from all protein-coding genes of human chromosomes. As evident in the recent nature papers, it is possible that those missing proteins may be low abundant in many cell types or expresse...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-06-10 | MSV000083952 | MassIVE
UnknownSafety of the PCSK9 inhibitor alirocumab: insights from 47 296 patient-years of observation.
Not available
S-EPMC11249957 | biostudies-literature
UnknownLipoprotein(a) and Benefit of PCSK9 Inhibition in Patients With Nominally Controlled LDL Cholesterol.
Not available
S-EPMC8822604 | biostudies-literature
UnknownApolipoprotein B, Residual Cardiovascular Risk After Acute Coronary Syndrome, and Effects of Alirocumab.
Not available
S-EPMC9422774 | biostudies-literature
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